ArticleScientific reports2022
Metabolomic response to collegiate football participation: Pre- and Post-season analysis.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Characterizing Human Oxidative, Anabolic and Glycolytic Metabolism in Athletes with Extreme Physiologies.Sports medicine - open · 2026Article
- Molecular abnormalities scale across three models of cerebral injury.Frontiers in molecular neuroscience · 2026Article
- NMR-Based Metabolomics Reveals Position-Specific Signatures Associated with Physical Demands in Professional Soccer Players.Biomedicines · 2025Article
- Early changes in urineMetabolomics : Official journal of the Metabolomic Society · 2025Article
- Alterations in mitochondrial energy metabolites following acute subconcussive head impacts among athletes with and without ADHD.iScience · 2025Article
- Based on Sportomics: Comparison of Physiological Status of Collegiate Sprinters in Different Pre-Competition Preparation Periods.Metabolites · 2024Article
- Metabolomic profiling of elite female soccer players: urinary biomarkers over a championship season.Metabolomics : Official journal of the Metabolomic Society · 2024Article
- Article
- The Use of Biofluid Markers to Evaluate the Consequences of Sport-Related Subconcussive Head Impact Exposure: A Scoping Review.Sports medicine - open · 2024Article
- Exercise Metabolome: Insights for Health and Performance.Metabolites · 2023Review
- Subtle impairments of perceptual-motor function and well-being are detectable among military cadets and college athletes with self-reported history of concussion.Frontiers in sports and active living · 2023Article
- Article
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Authors and funding
9 authors.
Funding
Abstract
Contact sports participation has been shown to have both beneficial and detrimental effects on health, however little is known about the metabolic sequelae of these effects. We aimed to identify metabolite alterations across a collegiate American football season. Serum was collected from 23 male collegiate football athletes before the athletic season (Pre) and after the last game (Post). Samples underwent nontargeted metabolomic profiling and 1131 metabolites were included for univariate, pathway enrichment, and multivariate analyses. Significant metabolites were assessed against head acceleration events (HAEs). 200 metabolites changed from Pre to Post (P < 0.05 and Q < 0.05); 160 had known identity and mapped to one of 57 pre-defined biological pathways. There was significant enrichment of metabolites belonging to five pathways (P < 0.05): xanthine, fatty acid (acyl choline), medium chain fatty acid, primary bile acid, and glycolysis, gluconeogenesis, and pyruvate metabolism. A set of 12 metabolites was sufficient to discriminate Pre from Post status, and changes in 64 of the 200 metabolites were also associated with HAEs (P < 0.05). In summary, the identified metabolites, and candidate pathways, argue there are metabolic consequences of both physical training and head impacts with football participation. These findings additionally identify a potential set of objective biomarkers of repetitive head injury.
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