ArticleScientific reports2022
Host microbiome responses to the Snake Fungal Disease pathogen (Ophidiomyces ophidiicola) are driven by changes in microbial richness.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 13 citations in OpenAlex.
- Health assessment and multipathogen surveillance of free-ranging snakes in the southeastern United States.Frontiers in veterinary science · 2026Article
- Oo-No: Ophidiomyces ophidiicola-bacterial interactions and the role of skin lipids in development of ophidiomycosis.PLoS pathogens · 2026Article
- Effects of snake fungal disease (ophidiomycosis) on the skin microbiome across two major experimental scales.Conservation biology : the journal of the Society for Conservation Biology · 2025Article
- Bridging Ecology and Microbiomes: Applying Ecological Theories in Host-associated Microbial Ecosystems.Current clinical microbiology reports · 2025Review
- Host genotype and infection status interact to shape microbiomes inParasitology · 2024Article
- Dual stressors of infection and warming can destabilize host microbiomes.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- Herptile gut microbiomes: a natural system to study multi-kingdom interactions between filamentous fungi and bacteria.mSphere · 2024Article
- Major Emerging Fungal Diseases of Reptiles and Amphibians.Pathogens (Basel, Switzerland) · 2023Review
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dermatophytic pathogens are a source of disturbance to the host microbiome, but the temporal progression of these disturbances is unclear. Here, we determined how Snake Fungal Disease, caused by Ophidiomyces ophidiicola, resulted in disturbance to the host microbiome. To assess disease effects on the microbiome, 22 Common Watersnakes (Nerodia sipedon) were collected and half were inoculated with O. ophidiicola. Epidermal swabs were collected weekly for use in microbiome and pathogen load characterization. For the inoculated treatment only, we found a significant effect of disease progression on microbial richness and Shannon diversity consistent with the intermediate disturbance hypothesis. When explicitly accounting for differences in assemblage richness, we found that β-diversity among snakes was significantly affected by the interaction of time and treatment group, with assemblages becoming more dissimilar across time in the inoculated, but not the control group. Also, differences between treatments in average microbiome composition became greater with time, but this interactive effect was not evident when accounting for assemblage richness. These results suggest that changes in composition of the host microbiome associated with disease largely occur due to changes in microbial richness related to disease progression.
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