ArticleNature communications2022
Biosynthetic gene cluster profiling predicts the positive association between antagonism and phylogeny in Bacillus.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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Who cites it
59 citing papers in PubMed.
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- Bacillus velezensis SQR9: a model biofertilizer strain for beneficial plant root-rhizobacterium interaction.Science China. Life sciences · 2026Review
- Genome-mining revealed biosurfactant production capacity and gene co-occurrence patterns in diverse ecosystems.Microbial cell factories · 2026Article
- Genome sequence ofMicrobiology resource announcements · 2026Article
- Metabolite interactions mediate beneficial alliances between Bacillus and Trichoderma for effective Fusarium wilt control.The ISME journal · 2026Article
- Indole-3-acetic acid-mediated self-rescue inISME communications · 2026Article
- The distribution and evolution of muscarine and the ibotenic acid biosynthetic gene cluster within the genusIMA fungus · 2026Article
- Colocalisation of lanthipeptide production with genetic exchange and defence systems across prokaryote genomes.BMC genomics · 2025Article
- Mechanisms of Enterobacter and Bacillus in promoting aerobic composting and immobilization of Cd in livestock and poultry manure.International microbiology : the official journal of the Spanish Society for Microbiology · 2025Article
- Bacillus velezensis Bac-9, isolated from kefir, possesses antifungal activity and improves resistance of tomato plant against whitefly Bemisia tabaci.BMC microbiology · 2025Article
- Genomic characterization and pathogenic mechanisms ofNew microbes and new infections · 2025Article
- Fast-growingbioRxiv : the preprint server for biology · 2025Article
- Bacterial social interactions in syntheticiMeta · 2025Article
- Evidence for Divergence of the Genus 'Microorganisms · 2025Article
- Modulation of rhizosphere microbiota byiMetaOmics · 2025Article
- Genome mining, structural elucidation and surface-active property of a new lipopeptide from Bacillus subtilis.Microbial cell factories · 2025Article
- Context matters: assessing the impacts of genomic background and ecology on microbial biosynthetic gene cluster evolution.mSystems · 2025Review
- Turning antagonists into allies: Bacterial-fungal interactions enhance the efficacy of controllingScience advances · 2025Article
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12 authors.
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Abstract
Understanding the driving forces and intrinsic mechanisms of microbial competition is a fundamental question in microbial ecology. Despite the well-established negative correlation between exploitation competition and phylogenetic distance, the process of interference competition that is exemplified by antagonism remains controversial. Here, we studied the genus Bacillus, a commonly recognized producer of multifarious antibiotics, to explore the role of phylogenetic patterns of biosynthetic gene clusters (BGCs) in mediating the relationship between antagonism and phylogeny. Comparative genomic analysis revealed a positive association between BGC distance and phylogenetic distance. Antagonistic tests demonstrated that the inhibition phenotype positively correlated with both phylogenetic and predicted BGC distance, especially for antagonistic strains possessing abundant BGCs. Mutant-based verification showed that the antagonism was dependent on the BGCs that specifically harbored by the antagonistic strain. These findings highlight that BGC-phylogeny coherence regulates the positive correlation between congeneric antagonism and phylogenetic distance, which deepens our understanding of the driving force and intrinsic mechanism of microbial interactions.
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