Evidence map›Paper›PMID 35197364›Full record

ArticleJournal of psychiatry & neuroscience : JPN

White matter microstructure and volume correlates of premenstrual dysphoric disorder.

Xuan Gu, Manon Dubol, Louise Stiernman, Johan Wikström, Andreas Hahn, Rupert Lanzenberger, C Neill Epperson, Marie Bixo, Inger Sundström-Poromaa, Erika Comasco

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of psychiatry & neuroscience : JPN. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Trial
  2. Article
  3. Biomarkers of reproductive psychiatric disorders.The British journal of psychiatry : the journal of mental science · 2025
    Review
  4. Characteristics of the amygdala and its subregions in premenstrual syndrome/premenstrual dysphoric disorder patients.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025
    Review
  5. Review
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Xuan GuFrom the Department of Neuroscience, Science for Life Laboratory, Uppsala University, Sweden (Gu, Dubol, Comasco); the Department of Clinical Sciences, Umeå University, Umeå, Sweden (Stiernman, Bixo); the Department of Surgical Sciences, Neuroradiology, Uppsala University, Sweden (Wikström); the Department of Psychiatry and Psychotherapy, Medical University of Vienna, Austria (Hahn, Lanzenberger); the Department of Psychiatry, University of Colorado School of Medicine, USA (Epperson); the Department of Women's and Children's Health, Uppsala University, Sweden (Sundström-Poromaa).
Manon DubolFrom the Department of Neuroscience, Science for Life Laboratory, Uppsala University, Sweden (Gu, Dubol, Comasco); the Department of Clinical Sciences, Umeå University, Umeå, Sweden (Stiernman, Bixo); the Department of Surgical Sciences, Neuroradiology, Uppsala University, Sweden (Wikström); the Department of Psychiatry and Psychotherapy, Medical University of Vienna, Austria (Hahn, Lanzenberger); the Department of Psychiatry, University of Colorado School of Medicine, USA (Epperson); the Department of Women's and Children's Health, Uppsala University, Sweden (Sundström-Poromaa).
Louise StiernmanFrom the Department of Neuroscience, Science for Life Laboratory, Uppsala University, Sweden (Gu, Dubol, Comasco); the Department of Clinical Sciences, Umeå University, Umeå, Sweden (Stiernman, Bixo); the Department of Surgical Sciences, Neuroradiology, Uppsala University, Sweden (Wikström); the Department of Psychiatry and Psychotherapy, Medical University of Vienna, Austria (Hahn, Lanzenberger); the Department of Psychiatry, University of Colorado School of Medicine, USA (Epperson); the Department of Women's and Children's Health, Uppsala University, Sweden (Sundström-Poromaa).
Johan WikströmFrom the Department of Neuroscience, Science for Life Laboratory, Uppsala University, Sweden (Gu, Dubol, Comasco); the Department of Clinical Sciences, Umeå University, Umeå, Sweden (Stiernman, Bixo); the Department of Surgical Sciences, Neuroradiology, Uppsala University, Sweden (Wikström); the Department of Psychiatry and Psychotherapy, Medical University of Vienna, Austria (Hahn, Lanzenberger); the Department of Psychiatry, University of Colorado School of Medicine, USA (Epperson); the Department of Women's and Children's Health, Uppsala University, Sweden (Sundström-Poromaa).
Andreas HahnFrom the Department of Neuroscience, Science for Life Laboratory, Uppsala University, Sweden (Gu, Dubol, Comasco); the Department of Clinical Sciences, Umeå University, Umeå, Sweden (Stiernman, Bixo); the Department of Surgical Sciences, Neuroradiology, Uppsala University, Sweden (Wikström); the Department of Psychiatry and Psychotherapy, Medical University of Vienna, Austria (Hahn, Lanzenberger); the Department of Psychiatry, University of Colorado School of Medicine, USA (Epperson); the Department of Women's and Children's Health, Uppsala University, Sweden (Sundström-Poromaa).
Rupert LanzenbergerFrom the Department of Neuroscience, Science for Life Laboratory, Uppsala University, Sweden (Gu, Dubol, Comasco); the Department of Clinical Sciences, Umeå University, Umeå, Sweden (Stiernman, Bixo); the Department of Surgical Sciences, Neuroradiology, Uppsala University, Sweden (Wikström); the Department of Psychiatry and Psychotherapy, Medical University of Vienna, Austria (Hahn, Lanzenberger); the Department of Psychiatry, University of Colorado School of Medicine, USA (Epperson); the Department of Women's and Children's Health, Uppsala University, Sweden (Sundström-Poromaa).
C Neill EppersonFrom the Department of Neuroscience, Science for Life Laboratory, Uppsala University, Sweden (Gu, Dubol, Comasco); the Department of Clinical Sciences, Umeå University, Umeå, Sweden (Stiernman, Bixo); the Department of Surgical Sciences, Neuroradiology, Uppsala University, Sweden (Wikström); the Department of Psychiatry and Psychotherapy, Medical University of Vienna, Austria (Hahn, Lanzenberger); the Department of Psychiatry, University of Colorado School of Medicine, USA (Epperson); the Department of Women's and Children's Health, Uppsala University, Sweden (Sundström-Poromaa).
Marie BixoFrom the Department of Neuroscience, Science for Life Laboratory, Uppsala University, Sweden (Gu, Dubol, Comasco); the Department of Clinical Sciences, Umeå University, Umeå, Sweden (Stiernman, Bixo); the Department of Surgical Sciences, Neuroradiology, Uppsala University, Sweden (Wikström); the Department of Psychiatry and Psychotherapy, Medical University of Vienna, Austria (Hahn, Lanzenberger); the Department of Psychiatry, University of Colorado School of Medicine, USA (Epperson); the Department of Women's and Children's Health, Uppsala University, Sweden (Sundström-Poromaa).
Inger Sundström-PoromaaFrom the Department of Neuroscience, Science for Life Laboratory, Uppsala University, Sweden (Gu, Dubol, Comasco); the Department of Clinical Sciences, Umeå University, Umeå, Sweden (Stiernman, Bixo); the Department of Surgical Sciences, Neuroradiology, Uppsala University, Sweden (Wikström); the Department of Psychiatry and Psychotherapy, Medical University of Vienna, Austria (Hahn, Lanzenberger); the Department of Psychiatry, University of Colorado School of Medicine, USA (Epperson); the Department of Women's and Children's Health, Uppsala University, Sweden (Sundström-Poromaa).
Erika ComascoFrom the Department of Neuroscience, Science for Life Laboratory, Uppsala University, Sweden (Gu, Dubol, Comasco); the Department of Clinical Sciences, Umeå University, Umeå, Sweden (Stiernman, Bixo); the Department of Surgical Sciences, Neuroradiology, Uppsala University, Sweden (Wikström); the Department of Psychiatry and Psychotherapy, Medical University of Vienna, Austria (Hahn, Lanzenberger); the Department of Psychiatry, University of Colorado School of Medicine, USA (Epperson); the Department of Women's and Children's Health, Uppsala University, Sweden (Sundström-Poromaa) erika.comasco@neuro.uu.se.
Science for Life Laboratory · SEUniversity of Colorado Denver · USMedical University of Vienna · ATUmeå University · SEUppsala University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPremenstrual dysphoric disorder (PMDD) is a mood disorder characterized by psychological and physical symptoms. Differences in white matter have been associated with affective and anxiety disorders, which share some symptoms with PMDD. However, whether white matter structure differs between the brains of individuals with PMDD and healthy controls is not known, nor is its relation to symptom severity.

methodsWe performed tract-based spatial statistics and voxel-based morphometry analyses of diffusion tensor imaging metrics and white matter volume, using 2 neuroimaging data sets (

resultsWe found greater fractional anisotropy in the left uncinate fasciculus ( LIMITATIONS: It is challenging to interpret group differences in diffusion tensor imaging metrics in terms of their underlying biophysical properties. The small size of the control group in the diffusion tensor imaging study may have prevented effects of interest from being detected.

conclusionThe findings of the present study provide evidence of differential cerebral white matter structure associated with PMDD and its symptoms.

Indexed as

Premenstrual Dysphoric DisorderWhite MatterAnisotropyBrainDiffusion Tensor ImagingFemaleHumansNeuroimaging

Identifiers

PMID35197364
PMCPMC9259386
OpenAlexW4214623181

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.