ArticleRMD open2022
Passive smoking in childhood and adulthood and risk of rheumatoid arthritis in women: results from the French E3N cohort study.
Article in RMD open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Pooled it
- Early-life animal and farming exposures and the risk of rheumatoid arthritis: findings from the E3N French cohort study.RMD open · 2025Trial
- Birth length and perinatal exposures and rheumatoid arthritis risk in the E3N cohort.RMD open · 2026Observational
- In utero and early life exposures to smoking are associated with systemic autoimmune rheumatic diseases.Seminars in arthritis and rheumatism · 2025Observational
- Osteoporosis and fracture risk are multifactorial in patients with inflammatory rheumatic diseases.Nature reviews. Rheumatology · 2024Review
- Association between secondhand smoke exposure and rheumatoid arthritis in US never-smoking adults: a cross-sectional study from NHANES.Scientific reports · 2024Article
- Association between oxidative balance score and rheumatoid arthritis in female: a cross-sectional study.BMC women's health · 2024Observational
- MALTectomy and psoriasis risk in women: A prospective study in the French E3N prospective cohort.PloS one · 2024Observational
- Prevalence of rheumatoid arthritis in Greece: results from the national health examination survey EMENO.Rheumatology international · 2023Article
- A Roadmap for Investigating Preclinical Autoimmunity Using Patient-Oriented and Epidemiologic Study Designs: Example of Rheumatoid Arthritis.Frontiers in immunology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe association between passive smoking exposure in childhood or in adulthood, and the risk of rheumatoid arthritis (RA) has been incompletely investigated. We aimed to assess the relationship between exposure to passive smoking and the risk of incident RA in a French prospective cohort of healthy women.
methodsThe E3N Study (
resultsAmong 79 806 women, 698 incident cases of RA were identified; 10 810 (13.5%) women were exposed to passive smoking in childhood, and 42 807 (53.6%) in adulthood. Median age at inclusion was 47.8 years. Passive smoking in childhood and in adulthood was associated with RA risk in all models (HRs (95% CIs) 1.24 (1.01 to 1.51) and 1.19 (1.02 to 1.40), respectively). The absolute risk of RA among never smokers with exposure to passive smoking in childhood and/or adulthood (47.6/100 000 person-years) was close to the risk of ever smokers with no passive smoking exposure (47.2/100 000 person-years), while it was highest in ever smokers also exposed to passive smoking (53.7/100 000 person-years).
conclusionExposure to passive smoking in childhood and/or adulthood increases the risk of RA by the same order than active smoking. Such exposure should be suppressed, especially in individuals at risk of RA.
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