Evidence map›Paper›PMID 35197325›Full record

ArticleJournal of the American Society of Nephrology : JASN2022

Association of Clonal Hematopoiesis of Indeterminate Potential with Worse Kidney Function and Anemia in Two Cohorts of Patients with Advanced Chronic Kidney Disease.

Caitlyn Vlasschaert, Amy J M McNaughton, Michael Chong, Elina K Cook, Wilma Hopman, Bryan Kestenbaum, Cassianne Robinson-Cohen, Jocelyn Garland, Sarah M Moran, Guillaume Paré and 6 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Society of Nephrology : JASN, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed, 2 pooled it
15.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 2 syntheses or guidelines pooled it, 100 citations in OpenAlex.

  1. Pooled it
  2. Clonal Hematopoiesis of Indeterminate Potential and Kidney Function Decline in the General Population.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2023
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  18. Clonal Hematopoiesis of Indeterminate Potential Influences Breast Cancer Outcomes in a Genotype-Specific Manner.Clinical cancer research : an official journal of the American Association for Cancer Research · 2025
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6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 2 countries.

Caitlyn VlasschaertDepartment of Medicine, Queen's University, Kingston, Ontario, Canada.
Amy J M McNaughtonDepartment of Pathology and Molecular Medicine, Queen's University, Kingston, Ontario, Canada.
Michael ChongPopulation Health Research Institute (PHRI), Hamilton, Ontario, Canada.
Elina K CookDepartment of Pathology and Molecular Medicine, Queen's University, Kingston, Ontario, Canada.
Wilma HopmanDepartment of Medicine, Queen's University, Kingston, Ontario, Canada.
Bryan KestenbaumDepartment of Medicine, University of Washington, Seattle, Washington.ORCID 0000-0003-4799-5968
Cassianne Robinson-CohenDepartment of Medicine, Vanderbilt University, Nashville, Tennessee.ORCID 0000-0003-4783-7046
Jocelyn GarlandDepartment of Medicine, Queen's University, Kingston, Ontario, Canada.
Sarah M MoranDepartment of Medicine, Queen's University, Kingston, Ontario, Canada.
Guillaume ParéPopulation Health Research Institute (PHRI), Hamilton, Ontario, Canada.
Catherine M ClaseDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada.ORCID 0000-0002-4538-5958
Mila TangSt. Paul's Hospital, Vancouver, British Colombia, Canada.ORCID 0000-0003-3459-5826
Adeera LevinDivision of Nephrology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Rachel HoldenDepartment of Medicine, Queen's University, Kingston, Ontario, Canada.
Michael J RauhDepartment of Pathology and Molecular Medicine, Queen's University, Kingston, Ontario, Canada.
Matthew B LanktreePopulation Health Research Institute (PHRI), Hamilton, Ontario, Canada.ORCID 0000-0002-5750-6286
Queen's University · CAPopulation Health Research Institute · CAImpact · CASt. Paul's Hospital · CAUniversity of British Columbia · CAUniversity of Washington · USVanderbilt University · US

Funding

BLRD VA I01 BX000320
6 · The paper itself

Abstract

backgroundClonal hematopoiesis of indeterminate potential (CHIP) is an inflammatory premalignant disorder resulting from acquired genetic mutations in hematopoietic stem cells. This condition is common in aging populations and associated with cardiovascular morbidity and overall mortality, but its role in CKD is unknown.

methodsWe performed targeted sequencing to detect CHIP mutations in two independent cohorts of 87 and 85 adults with an eGFR<60 ml/min per 1.73m

resultsAt baseline, CHIP was detected in 18 of 87 (21%) and 25 of 85 (29%) cohort participants. Participants with CHIP were at higher risk of kidney failure, as predicted by the Kidney Failure Risk Equation (KFRE), compared with those without CHIP. Individuals with CHIP manifested a 2.2-fold increased risk of a 50% decline in eGFR or ESKD over 5 years of follow-up (hazard ratio 2.2; 95% confidence interval, 1.2 to 3.8) in a Cox proportional hazard model adjusted for age, sex, and baseline eGFR. The addition of CHIP to 2-year and 5-year calibrated KFRE risk models improved ESKD predictions. Those with CHIP also had lower hemoglobin, higher ferritin, and higher red blood cell mean corpuscular volume versus those without CHIP.

conclusionsIn this exploratory analysis of individuals with preexisting CKD, CHIP was associated with higher baseline KFRE scores, greater progression of CKD, and anemia. Further research is needed to define the nature of the relationship between CHIP and kidney disease progression.

Indexed as

AnemiaRenal InsufficiencyRenal Insufficiency, ChronicAdultClonal HematopoiesisDisease ProgressionFemaleHumansKidneyMaleRisk Factorsanemiachronic inflammationchronic renal insufficiencyclonal hematopoiesisclone cellscohort studieshematopoiesismacrophages

Identifiers

PMID35197325
PMCPMC9063886
OpenAlexW4213450385

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.