ArticleBMC biology2022
Verticillium dahliae CFEM proteins manipulate host immunity and differentially contribute to virulence.
Article in BMC biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 53 citations in OpenAlex.
- The deletion of a major facilitator superfamily geneMicrobiology spectrum · 2026Article
- Genome-Wide Identification of CFEM Proteins inPlants (Basel, Switzerland) · 2026Article
- Functional characterization of a CFEM domain-containing protein in the mycoparasitic fungus Clonostachys rosea reveals antimicrobial activity and a role in conidiation.Molecular genetics and genomics : MGG · 2026Article
- GhSTH-2 Integrates Host Redox Signalling and Effector Recognition and Confers Resistance Against Verticillium dahliae in Cotton.Molecular plant pathology · 2026Article
- An integrative defense mechanism mediated by GhBsr-d1L7 and GhERD10 confers resistance to Verticillium dahliae in cotton.BMC biology · 2026Article
- CFEM proteins: unique to fungi with essential roles in plant host interactions.Frontiers in fungal biology · 2026Review
- Mitochondrial Complex Member VdNuo1 Recruits Superoxide Dismutases VdSOD2/4 to Maintain Superoxide Anion Homeostasis During Pathogenesis in Verticillium dahliae.Molecular plant pathology · 2025Article
- Transcriptome Analysis and CFEM Gene Overexpression inPathogens (Basel, Switzerland) · 2025Article
- A Cotton Laccase Confers Disease Resistance Against Verticillium dahliae by Promoting Cell Wall Lignification.Molecular plant pathology · 2025Article
- A Novel CFEM Effector inInternational journal of molecular sciences · 2025Article
- A powdery mildew core effector protein targets the host endosome tethering complexes HOPS and CORVET in barley.Plant physiology · 2025Article
- Screening and transcriptomic analysis of anti-Frontiers in microbiology · 2025Article
- CAP superfamily proteins (VdPRYs) manipulate plant immunity and contribute to the virulence ofMycology · 2025Article
- Article
- Re-localization of a repeat-containing fungal effector by apoplastic protein Chitinase-like 1 blocks its toxicity.Nature communications · 2024Article
- Dual Transcriptome Analysis Reveals the Changes in Gene Expression in Both Cotton andJournal of fungi (Basel, Switzerland) · 2024Article
- An iron-binding protein of entomopathogenic fungus suppresses the proliferation of host symbiotic bacteria.Microbiome · 2024Article
- CgCFEM1 Is Required for the Full Virulence ofInternational journal of molecular sciences · 2024Article
- SreC-dependent adaption to host iron environments regulates the transition of trophic stages and developmental processes of Curvularia lunata.Molecular plant pathology · 2024Article
- The elicitor VP2 from Verticillium dahliae triggers defence response in cotton.Plant biotechnology journal · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVerticillium dahliae is a fungal pathogen that causes a vascular wilt on many economically important crops. Common fungal extracellular membrane (CFEM) domain proteins including secreted types have been implicated in virulence, but their roles in this pathogen are still unknown.
resultsNine secreted small cysteine-rich proteins (VdSCPs) with CFEM domains were identified by bioinformatic analyses and their differential suppression of host immune responses were evaluated. Two of these proteins, VdSCP76 and VdSCP77, localized to the plant plasma membrane owing to their signal peptides and mediated broad-spectrum suppression of all immune responses induced by typical effectors. Deletion of either VdSCP76 or VdSCP77 significantly reduced the virulence of V. dahliae on cotton. Furthermore, VdSCP76 and VdSCP77 suppressed host immunity through the potential iron binding site conserved in CFEM family members, characterized by an aspartic acid residue in seven VdSCPs (Asp-type) in contrast with an asparagine residue (Asn-type) in VdSCP76 and VdSCP77. V. dahliae isolates carrying the Asn-type CFEM members were more virulent on cotton than those carrying the Asp-type.
conclusionsIn the iron-insufficient xylem, V. dahliae is likely to employ the Asp-type CFEM members to chelate iron, and Asn-type CFEM members to suppress immunity, for successful colonization and propagation in host plants.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.