Evidence map›Paper›PMID 35196988›Full record

SynthesisBMC cardiovascular disorders2022

Clinical outcomes of patients with hepatic insufficiency undergoing transcatheter aortic valve implantation: a systematic review and meta-analysis.

Wenkai Jiang, Zeyi Cheng, Shiyan Tu, Xing Wang, Caifei Xiang, Wence Zhou, Lin Chen

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC cardiovascular disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Wenkai Jiang *The First Clinical Medical College of Lanzhou University, No.222, Tianshui Road (South), Chengguan District, Lanzhou City, 730000, Gansu Province, China.
Zeyi Cheng *Department of Cardiac Surgery, Ruijin Hospital affiliated to School of Medicine, Shanghai Jiao Tong University, No.197, Ruijin Road (Second), Shanghai City, 200025, China.
Shiyan TuThe First Clinical Medical College of Lanzhou University, No.222, Tianshui Road (South), Chengguan District, Lanzhou City, 730000, Gansu Province, China.
Xing WangThe First Clinical Medical College of Lanzhou University, No.222, Tianshui Road (South), Chengguan District, Lanzhou City, 730000, Gansu Province, China.
Caifei XiangThe Second Clinical Medical College of Lanzhou University, No.222, Tianshui Road (South), Chengguan District, Lanzhou City, 730000, Gansu Province, China.
Wence ZhouDepartment of General Surgery, The First Hospital of Lanzhou University, No. 1, Donggangxi Road, Chengguan District, Lanzhou City, 730000, Gansu Province, China. zhouwc129@163.com.
Lin ChenDepartment of Infectious Diseases, The First Hospital of Lanzhou University, No. 1, Donggangxi Road, Chengguan District, Lanzhou City, 730000, Gansu Province, China. chenlinfree@126.com.
Lanzhou University · CNFirst Hospital of Lanzhou University · CNShanghai Jiao Tong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTranscatheter aortic valve implantation (TAVI) is currently a common treatment in high-risk aortic stenosis patients, but the impact of hepatic insufficiency on prognosis after TAVI is debatable and whether TAVI is superior to surgical aortic valve replacement (SAVR) in patients with hepatic insufficiency is uncertain.

objectiveTo investigate the effect of abnormal liver function on the outcome and safety after TAVI and whether TAVI is superior to SAVR in patients with hepatic insufficiency.

methodsPubMed, Embase, the Cochrane Library and Web of Science were systematically searched from inception up to 26 November 2021. Studies were eligible if mortality and complications after TAVI in patients with and without hepatic insufficiency, or mortality and complications for TAVI versus SAVR in patients with hepatic insufficiency were reported. The Newcastle-Ottawa scale (NOS) was used to evaluate the quality of each study. This meta-analysis was registered with PROSPERO (CRD42021253423) and was carried out by using RevMan 5.3 and Stata 14.0.

resultsThis meta-analysis of 21 studies assessed a total of 222,694 patients. Hepatic insufficiency was associated with higher short-term (in-hospital or 30-day) mortality [OR = 1.62, 95% CI (1.18 to 2.21), P = 0.003] and 1-2 years mortality [HR = 1.64, 95% CI (1.42 to 1.89), P < 0.00001] after TAVI. Between TAVI and SAVR in patients with hepatic insufficiency, there was a statistically significant difference in in-hospital mortality [OR = 0.46, 95% CI (0.27 to 0.81), P = 0.007], the occurrence rate of blood transfusions [OR = 0.29, 95% CI (0.22 to 0.38), P < 0.00001] and the occurrence rate of acute kidney injury [OR = 0.55, 95% CI (0.33 to 0.91), P = 0.02].

conclusionsTAVI patients with hepatic insufficiency may have negative impact both on short-term (in-hospital or 30-day) and 1-2-years mortality. For patients with hepatic insufficiency, TAVI could be a better option than SAVR.

Indexed as

Aortic Valve StenosisHeart Valve ProsthesisHeart Valve Prosthesis ImplantationHepatic InsufficiencyTranscatheter Aortic Valve ReplacementAortic ValveHumansRisk FactorsTreatment OutcomeHepatic insufficiencyMeta-analysisMortalitySurgical aortic valve replacementTranscatheter aortic valve implantation

Identifiers

PMID35196988
PMCPMC8864911
OpenAlexW4213171835

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.