Evidence map›Paper›PMID 35196901›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2022

Effect of lung pericyte-like cell ablation on the bleomycin model of injury and repair.

Chi F Hung, Carole L Wilson, Yu-Hua Chow, Wayne C Liles, Sina A Gharib, William A Altemeier, Lynn M Schnapp

Open access · hybridAbstract read
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Pericytes in tissue fibrosis.American journal of physiology. Cell physiology · 2025
    Review
  3. Emerging Concepts in Fibroblast Biology and Progressive Pulmonary Fibrosis.Seminars in respiratory and critical care medicine · 2025
    Review
  4. Article
  5. MULTIFACETED ROLES OF PERICYTES IN LUNG INJURY AND REPAIR.Transactions of the American Clinical and Climatological Association · 2025
    Review
  6. Article
  7. Article
  8. Article
  9. Multiple Fibroblast Subtypes Contribute to Matrix Deposition in Pulmonary Fibrosis.American journal of respiratory cell and molecular biology · 2023
    Article
  10. Lung pericytes as mediators of inflammation.American journal of physiology. Lung cellular and molecular physiology · 2023
    Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Chi F HungDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of Washington, Seattle, Washington.ORCID 0000-0001-6408-0773
Carole L WilsonDivision of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin.ORCID 0000-0001-6692-0430
Yu-Hua ChowDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of Washington, Seattle, Washington.
Wayne C LilesCenter for Lung Biology, University of Washington, Seattle, Washington.
Sina A GharibDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of Washington, Seattle, Washington.ORCID 0000-0002-2480-4367
William A AltemeierDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of Washington, Seattle, Washington.ORCID 0000-0001-8860-405X
Lynn M SchnappDivision of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin.ORCID 0000-0002-9189-7567
University of Washington · USUniversity of Wisconsin–Madison · US

Funding

Translational Science Laboratory Shared ResourceP30CA138313 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI RAYMOND N. DUBOIS · 2009 to 2026
$42.7M
Role of pericytes in scleroderma skin and lung fibrosisR01HL133751 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI FEGHALI-BOSTWICK, CAROL A., SCHNAPP, LYNN M · 2017 to 2020
$2.0M
PDGFR-beta+ stromal cells as critical regulators of immune response to tissue injuryR01HL122895 · NHLBI · UNIVERSITY OF WASHINGTON · PI ALTEMEIER, WILLIAM A · 2015 to 2018
$1.7M
Role of integrin alpha 8 in resolution of lung injury and repairK08HL127075 · NHLBI · UNIVERSITY OF WASHINGTON · PI HUNG, CHI F · 2015 to 2019
$778k
Application of single-cell trajectory analysis in single-cell transcriptomics to elucidate the biology of lung pericytes in injury, repair, and regenerationR03HL155075 · NHLBI · UNIVERSITY OF WASHINGTON · PI HUNG, CHI F · 2022 to 2023
$177k
NCI NIH HHS P30 CA138313NHLBI NIH HHS K08 HL127075NHLBI NIH HHS R01 HL122895NHLBI NIH HHS R01 HL133751NHLBI NIH HHS R03 HL155075
6 · The paper itself

Abstract

We previously showed that pericyte-like cells derived from the FoxD1-lineage contribute to myofibroblasts following bleomycin-induced lung injury. However, their functional significance in lung fibrosis remains unknown. In this study, we used a model of lung pericyte-like cell ablation to test the hypothesis that pericyte-like cell ablation attenuates lung fibrosis in bleomycin-induced lung injury. Lung fibrosis was induced by intratracheal instillation of bleomycin. To ablate pericyte-like cells in the lung, diphtheria toxin (DT) was administered to

Indexed as

Lung InjuryPulmonary FibrosisAnimalsBleomycinBronchoalveolar Lavage FluidHydroxyprolineLungMiceMice, Inbred C57BLPericytesBleomycinHydroxyprolinebleomcyinfibrosisinflammationlung pericytesmyofibroblasts

Identifiers

PMID35196901
PMCPMC8993536
OpenAlexW4213451017

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.