Evidence map›Paper›PMID 35196796›Full record

ArticleMicrobiology spectrum2022

Limited Recognition of Highly Conserved Regions of SARS-CoV-2.

Srividhya Swaminathan, Katie E Lineburg, George R Ambalathingal, Pauline Crooks, Emma J Grant, Sonali V Mohan, Jyothy Raju, Archana Panikkar, Laetitia Le Texier, Zheng Wei Marcus Tong and 7 more

Open access · goldAbstract read
In one paragraph

Article in Microbiology spectrum, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 1 country.

Srividhya SwaminathanQIMR Berghofer Centre for Immunotherapy and Vaccine Development and Translational and Human Immunology Laboratory, Department of Immunology, QIMR Berghofer Medical Research Institutegrid.1049.c, Brisbane, Queensland, Australia.
Katie E LineburgQIMR Berghofer Centre for Immunotherapy and Vaccine Development and Translational and Human Immunology Laboratory, Department of Immunology, QIMR Berghofer Medical Research Institutegrid.1049.c, Brisbane, Queensland, Australia.
George R AmbalathingalQIMR Berghofer Centre for Immunotherapy and Vaccine Development and Translational and Human Immunology Laboratory, Department of Immunology, QIMR Berghofer Medical Research Institutegrid.1049.c, Brisbane, Queensland, Australia.
Pauline CrooksQIMR Berghofer Centre for Immunotherapy and Vaccine Development and Translational and Human Immunology Laboratory, Department of Immunology, QIMR Berghofer Medical Research Institutegrid.1049.c, Brisbane, Queensland, Australia.
Emma J GrantDepartment of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe Universitygrid.1018.8, Melbourne, Victoria, Australia.
Sonali V MohanFaculty of Medicine, The University of Queenslandgrid.1003.2, Brisbane, Queensland, Australia.
Jyothy RajuQIMR Berghofer Centre for Immunotherapy and Vaccine Development and Translational and Human Immunology Laboratory, Department of Immunology, QIMR Berghofer Medical Research Institutegrid.1049.c, Brisbane, Queensland, Australia.
Archana PanikkarQIMR Berghofer Centre for Immunotherapy and Vaccine Development and Translational and Human Immunology Laboratory, Department of Immunology, QIMR Berghofer Medical Research Institutegrid.1049.c, Brisbane, Queensland, Australia.
Laetitia Le TexierQIMR Berghofer Centre for Immunotherapy and Vaccine Development and Translational and Human Immunology Laboratory, Department of Immunology, QIMR Berghofer Medical Research Institutegrid.1049.c, Brisbane, Queensland, Australia.
Zheng Wei Marcus TongSchool of Chemistry and Molecular Biosciences, The University of Queenslandgrid.1003.2, Brisbane, Queensland, Australia.
Keng Yih ChewSchool of Chemistry and Molecular Biosciences, The University of Queenslandgrid.1003.2, Brisbane, Queensland, Australia.
Michelle A NellerQIMR Berghofer Centre for Immunotherapy and Vaccine Development and Translational and Human Immunology Laboratory, Department of Immunology, QIMR Berghofer Medical Research Institutegrid.1049.c, Brisbane, Queensland, Australia.
Kirsty R ShortSchool of Chemistry and Molecular Biosciences, The University of Queenslandgrid.1003.2, Brisbane, Queensland, Australia.
Harsha GowdaFaculty of Medicine, The University of Queenslandgrid.1003.2, Brisbane, Queensland, Australia.
Stephanie GrasDepartment of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe Universitygrid.1018.8, Melbourne, Victoria, Australia.
Rajiv KhannaQIMR Berghofer Centre for Immunotherapy and Vaccine Development and Translational and Human Immunology Laboratory, Department of Immunology, QIMR Berghofer Medical Research Institutegrid.1049.c, Brisbane, Queensland, Australia.
Corey SmithQIMR Berghofer Centre for Immunotherapy and Vaccine Development and Translational and Human Immunology Laboratory, Department of Immunology, QIMR Berghofer Medical Research Institutegrid.1049.c, Brisbane, Queensland, Australia.
QIMR Berghofer Medical Research Institute · AUUniversity of Queensland · AULa Trobe University · AU

Funding

Australian Research Council DE180100512Australian Research Council DE210101479Department of Health | National Health and Medical Research Council (NHMRC) 1110429Department of Health | National Health and Medical Research Council (NHMRC) 1159272Medical Research Future Fund APP2005654QIMR Berghofer Medical Research Institute (QIMR)
6 · The paper itself

Abstract

Understanding the immune response to severe acute respiratory syndrome coronavirus (SARS-CoV-2) is critical to overcome the current coronavirus disease (COVID-19) pandemic. Efforts are being made to understand the potential cross-protective immunity of memory T cells, induced by prior encounters with seasonal coronaviruses, in providing protection against severe COVID-19. In this study we assessed T-cell responses directed against highly conserved regions of SARS-CoV-2. Epitope mapping revealed 16 CD8

Indexed as

Amino Acid SequenceCD8-Positive T-LymphocytesConserved SequenceCoronavirusCOVID-19Cross ReactionsEpitope MappingEpitopes, T-LymphocyteHumansMemory T CellsSARS-CoV-2Sequence AlignmentSpike Glycoprotein, CoronavirusEpitopes, T-LymphocyteSpike Glycoprotein, Coronavirusantigen-specific CD8+ T cellsconservationCOVID-19SARS-CoV-2

Identifiers

PMID35196796
PMCPMC8865427
OpenAlexW4213432985

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.