Evidence map›Paper›PMID 35196795›Full record

ArticleMicrobiology spectrum2022

NrtR Mediated Regulation of H1-T6SS in Pseudomonas aeruginosa.

Xinxin Zhang, Liwen Yin, Qi Liu, Dan Wang, Congjuan Xu, Xiaolei Pan, Fang Bai, Zhihui Cheng, Weihui Wu, Yongxin Jin

Open access · goldAbstract read
In one paragraph

Article in Microbiology spectrum, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.4field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Regulation of NADPathogens (Basel, Switzerland) · 2025
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  3. Frontiers in microbiology · 2025
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  4. Article
  5. Review
  6. Review
  7. Impact of phage predation onRNA biology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Xinxin ZhangState Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Molecular Microbiology and Technology of the Ministry of Education, Department of Microbiology, College of Life Sciences, Nankai Universitygrid.216938.7, Tianjin, China.
Liwen YinState Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Molecular Microbiology and Technology of the Ministry of Education, Department of Microbiology, College of Life Sciences, Nankai Universitygrid.216938.7, Tianjin, China.
Qi LiuState Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Molecular Microbiology and Technology of the Ministry of Education, Department of Microbiology, College of Life Sciences, Nankai Universitygrid.216938.7, Tianjin, China.
Dan WangState Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Molecular Microbiology and Technology of the Ministry of Education, Department of Microbiology, College of Life Sciences, Nankai Universitygrid.216938.7, Tianjin, China.
Congjuan XuState Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Molecular Microbiology and Technology of the Ministry of Education, Department of Microbiology, College of Life Sciences, Nankai Universitygrid.216938.7, Tianjin, China.
Xiaolei PanState Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Molecular Microbiology and Technology of the Ministry of Education, Department of Microbiology, College of Life Sciences, Nankai Universitygrid.216938.7, Tianjin, China.
Fang BaiState Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Molecular Microbiology and Technology of the Ministry of Education, Department of Microbiology, College of Life Sciences, Nankai Universitygrid.216938.7, Tianjin, China.ORCID 0000-0003-0639-8104
Zhihui ChengState Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Molecular Microbiology and Technology of the Ministry of Education, Department of Microbiology, College of Life Sciences, Nankai Universitygrid.216938.7, Tianjin, China.
Weihui WuState Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Molecular Microbiology and Technology of the Ministry of Education, Department of Microbiology, College of Life Sciences, Nankai Universitygrid.216938.7, Tianjin, China.ORCID 0000-0002-9017-0091
Yongxin JinState Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Molecular Microbiology and Technology of the Ministry of Education, Department of Microbiology, College of Life Sciences, Nankai Universitygrid.216938.7, Tianjin, China.ORCID 0000-0002-1449-6735
Nankai University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

NrtR is a Nudix-related transcriptional regulator that is distributed among diverse bacteria and plays an important role in modulating bacterial intracellular NAD homeostasis. Previously, we showed that NrtR influences the T3SS expression and pathogenesis of Pseudomonas aeruginosa and demonstrated that NrtR mediates T3SS regulation through the cAMP/Vfr pathway. In the present study, we found that mutation of the

Indexed as

Gene Expression Regulation, BacterialBacterial ProteinsOperonPromoter Regions, GeneticPseudomonas aeruginosaRNA, BacterialTranscription, GeneticType III Secretion SystemsType VI Secretion SystemsVirulenceVirulence FactorsBacterial ProteinsRNA, BacterialType III Secretion SystemsType VI Secretion SystemsVirulence FactorsH1-T6SSNrtRP. aeruginosarsmYrsmZ

Identifiers

PMID35196795
PMCPMC8865458
OpenAlexW4213450850

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.