ArticleBiophysical journal2022
Interplay between Brownian motion and cross-linking controls bundling dynamics in actin networks.
Article in Biophysical journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 16 citations in OpenAlex.
- Rethinking contractility in active cytoskeletal matter.Biophysical journal · 2026Article
- Article
- A coarse-grained simulation model for colloidal self-assemblySoft matter · 2023Article
- Organization and dynamics of cross-linked actin filaments in confined environments.Biophysical journal · 2023Article
- Kinetochore- and chromosome-driven transition of microtubules into bundles promotes spindle assembly.Nature communications · 2022Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
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Abstract
Morphology changes in cross-linked actin networks are important in cell motility, division, and cargo transport. Here, we study the transition from a weakly cross-linked network of actin filaments to a heavily cross-linked network of actin bundles through microscopic Brownian dynamics simulations. We show that this transition occurs in two stages: first, a composite bundle network of small and highly aligned bundles evolves from cross-linking of individual filaments and, second, small bundles coalesce into the clustered bundle state. We demonstrate that Brownian motion speeds up the first stage of this process at a faster rate than the second. We quantify the time to reach the composite bundle state and show that it strongly increases as the mesh size increases only when the concentration of cross-links is small and that it remains roughly constant if we decrease the relative ratio of cross-linkers as we increase the actin concentration. Finally, we examine the dependence of the bundling timescale on filament length, finding that shorter filaments bundle faster because they diffuse faster.
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