ArticleCell reports2022
Gain control by sparse, ultra-slow glycinergic synapses.
Article in Cell reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Rod photoreceptors control the ON vs OFF polarity of cone-signaling neurons.Communications biology · 2026Article
- Layer-specific anatomical and physiological features of the retina's neurovascular unit.Current biology : CB · 2025Article
- Changes in glycinergic neurotransmission alter mammalian retinal information processing.Frontiers in molecular neuroscience · 2025Article
- Asymmetries in the Architecture of ON and OFF Arbors in ON-OFF Direction-Selective Ganglion Cells.The Journal of comparative neurology · 2025Article
- ON and OFF starburst amacrine cells are controlled by distinct cholinergic pathways.The Journal of general physiology · 2024Article
- GABAergic Inhibition Controls Receptive Field Size, Sensitivity, and Contrast Preference of Direction Selective Retinal Ganglion Cells Near the Threshold of Vision.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- A sign-inverted receptive field of inhibitory interneurons provides a pathway for ON-OFF interactions in the retina.Nature communications · 2023Article
- A circuit suppressing retinal drive to the optokinetic system during fast image motion.Nature communications · 2023Article
- Article
- Two mechanisms for direction selectivity in a model of the primate starburst amacrine cell.Visual neuroscience · 2023Article
- New insights into retinal circuits through EM connectomics: what we have learnt and what remains to be learned.Frontiers in ophthalmology · 2023Review
- Starburst amacrine cells form gap junctions in the early postnatal stage of the mouse retina.Frontiers in cellular neuroscience · 2023Article
- Article
- Distinct inhibitory pathways control velocity and directional tuning in the mouse retina.Current biology : CB · 2022Article
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Authors and funding
12 authors.
Funding
Abstract
In the retina, ON starburst amacrine cells (SACs) play a crucial role in the direction-selective circuit, but the sources of inhibition that shape their response properties remain unclear. Previous studies demonstrate that ∼95% of their inhibitory synapses are GABAergic, yet we find that the light-evoked inhibitory currents measured in SACs are predominantly glycinergic. Glycinergic inhibition is extremely slow, relying on non-canonical glycine receptors containing α4 subunits, and is driven by both the ON and OFF retinal pathways. These attributes enable glycine inputs to summate and effectively control the output gain of SACs, expanding the range over which they compute direction. Serial electron microscopic reconstructions reveal three specific types of ON and OFF narrow-field amacrine cells as the presumptive sources of glycinergic inhibition. Together, these results establish an unexpected role for specific glycinergic amacrine cells in the retinal computation of stimulus direction by SACs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.