Evidence map›Paper›PMID 35196451›Full record

ArticleJournal of natural products2022

Halogenated Metal-Binding Compounds from Shipworm Symbionts.

Bailey W Miller, Eric W Schmidt, Gisela P Concepcion, Margo G Haygood

Abstract read
In one paragraph

Article in Journal of natural products, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Nobachelins, new siderophores fromSynthetic and systems biotechnology · 2023
    Article
  5. Review
  6. Mining Small Molecules fromMetabolites · 2022
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Bailey W MillerDepartment of Medicinal Chemistry, University of Utah, Salt Lake City, Utah 84112, United States.ORCID 0000-0003-3204-3235
Eric W SchmidtDepartment of Medicinal Chemistry, University of Utah, Salt Lake City, Utah 84112, United States.ORCID 0000-0001-5839-694X
Gisela P ConcepcionThe Marine Science Institute, University of the Philippines, Diliman, Quezon City 1101, Philippines.
Margo G HaygoodDepartment of Medicinal Chemistry, University of Utah, Salt Lake City, Utah 84112, United States.ORCID 0000-0001-5277-9544

Funding

Diverse Drug Lead Compounds from Bacterial Symbionts in Philippine MollusksU19TW008163 · FIC · UNIVERSITY OF UTAH · PI HAYGOOD, MARGO GENEVIEVE · 2014 to 2018
$5.2M
Symbiosis and Chemical Diversity GenerationR35GM122521 · NIGMS · UNIVERSITY OF UTAH · PI SCHMIDT, ERIC W · 2017 to 2021
$2.9M
FIC NIH HHS U19 TW008163NIGMS NIH HHS R35 GM122521
6 · The paper itself

Abstract

Bacteria use small molecules to impose strict regulation over the acquisition, uptake, and sequestration of transition metal ions. Low-abundance nutrient metals, such as Fe(III), need to be scavenged from the environment by high-affinity chelating molecules called siderophores. Conversely, metal ions that become toxic at high concentrations need to be sequestered and detoxified. Often, bacteria produce a suite of compounds that bind various metal ions at different affinities in order to maintain homeostasis. Turnerbactin, a triscatecholate siderophore isolated from the intracellular shipworm symbiont

Indexed as

Ferric CompoundsSiderophoresBacteriaBiological TransportIronFerric CompoundsIronSiderophores

Identifiers

PMID35196451
PMCPMC8961882

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.