Evidence map›Paper›PMID 35196127›Full record

ArticlemBio2022

Coexistence of Ammonium Transporter and Channel Mechanisms in Amt-Mep-Rh Twin-His Variants Impairs the Filamentation Signaling Capacity of Fungal Mep2 Transceptors.

Gordon Williamson, Ana Sofia Brito, Adriana Bizior, Giulia Tamburrino, Gaëtan Dias Mirandela, Thomas Harris, Paul A Hoskisson, Ulrich Zachariae, Anna Maria Marini, Mélanie Boeckstaens and 1 more

Open access · goldAbstract read
In one paragraph

Article in mBio, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Construction of RecombinantMicroorganisms · 2025
    Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. The Exploring Functional Role of Ammonium Transporters ofInternational journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Gordon Williamson *Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclydegrid.11984.35, Glasgow, United Kingdom.
Ana Sofia Brito *Biology of Membrane Transport Laboratory, Department of Molecular Biology, Université Libre de Bruxellesgrid.4989.c, Gosselies, Belgium.
Adriana Bizior *Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclydegrid.11984.35, Glasgow, United Kingdom.
Giulia TamburrinoComputational Biology, School of Life Sciences, University of Dundeegrid.8241.f, Dundee, United Kingdom.
Gaëtan Dias MirandelaStrathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclydegrid.11984.35, Glasgow, United Kingdom.
Thomas HarrisStrathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclydegrid.11984.35, Glasgow, United Kingdom.
Paul A HoskissonStrathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclydegrid.11984.35, Glasgow, United Kingdom.ORCID 0000-0003-4332-1640
Ulrich ZachariaeComputational Biology, School of Life Sciences, University of Dundeegrid.8241.f, Dundee, United Kingdom.
Anna Maria MariniBiology of Membrane Transport Laboratory, Department of Molecular Biology, Université Libre de Bruxellesgrid.4989.c, Gosselies, Belgium.
Mélanie BoeckstaensBiology of Membrane Transport Laboratory, Department of Molecular Biology, Université Libre de Bruxellesgrid.4989.c, Gosselies, Belgium.
Arnaud JavelleStrathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclydegrid.11984.35, Glasgow, United Kingdom.ORCID 0000-0002-3611-5737
University of Strathclyde · GBUniversité Libre de Bruxelles · BEUniversity of Dundee · GB

Funding

tenovus scotland S17-07UKRI | Natural Environment Research Council (NERC) NE/M001415/1
6 · The paper itself

Abstract

Ammonium translocation through biological membranes, by the ubiquitous Amt-Mep-Rh family of transporters, plays a key role in all domains of life. Two highly conserved histidine residues protrude into the lumen of the pore of these transporters, forming the family's characteristic Twin-His motif. It has been hypothesized that the motif is essential to confer the selectivity of the transport mechanism. Here, using a combination of

Indexed as

Ammonium CompoundsCation Transport ProteinsEscherichia coli ProteinsSaccharomyces cerevisiae ProteinsCandida albicansEscherichia coliFungal ProteinsHumansMembrane Transport ProteinsSaccharomyces cerevisiaeSignal TransductionTranslocation, GeneticAmmonium CompoundsAmtB protein, E coliCation Transport ProteinsEscherichia coli ProteinsFungal ProteinsMembrane Transport ProteinsMEP2 protein, S cerevisiaeSaccharomyces cerevisiae Proteinsammonium assimilationCandida albicansEscherichia colifungal filamentationSaccharomyces cerevisiaesecondary transporter mechanism

Identifiers

PMID35196127
PMCPMC9040831
OpenAlexW4213413289

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.