Evidence map›Paper›PMID 35196125›Full record

ArticlemSphere2022

Vaccine-Induced, High-Magnitude HIV Env-Specific Antibodies with Fc-Mediated Effector Functions Are Insufficient to Protect Infant Rhesus Macaques against Oral SHIV Infection.

Alan D Curtis, Pooja T Saha, Maria Dennis, Stella J Berendam, Pratamesh Ramasubramanian, Kaitlyn A Cross, S Munir Alam, Guido Ferrari, Pamela A Kozlowski, Genevieve G Fouda and 5 more

Open access · goldAbstract read
In one paragraph

Article in mSphere, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Frontiers in immunology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 1 country.

Alan D CurtisDepartment of Microbiology and Immunology, School of Medicine, University of North Carolina at Chapel Hillgrid.10698.36, Chapel Hill, North Carolina, USA.
Pooja T SahaDepartment of Biostatistics, Gillings School of Public Health, University of North Carolina at Chapel Hillgrid.10698.36, Chapel Hill, North Carolina, USA.ORCID 0000-0002-2317-6311
Maria DennisDuke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA.
Stella J BerendamDuke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA.
Pratamesh RamasubramanianDepartment of Surgery, Duke University School of Medicinegrid.471396.e, Durham, North Carolina, USA.
Kaitlyn A CrossDepartment of Biostatistics, Gillings School of Public Health, University of North Carolina at Chapel Hillgrid.10698.36, Chapel Hill, North Carolina, USA.
S Munir AlamDuke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA.ORCID 0000-0003-0941-0703
Guido FerrariDuke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA.
Pamela A KozlowskiDepartment of Microbiology, Immunology and Parasitology, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA.
Genevieve G FoudaDuke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA.ORCID 0000-0002-0960-1019
Michael G HudgensDepartment of Biostatistics, Gillings School of Public Health, University of North Carolina at Chapel Hillgrid.10698.36, Chapel Hill, North Carolina, USA.
Koen K A Van RompayCalifornia National Primate Research Center, University of California at Davis, Davis, California, USA.ORCID 0000-0002-7375-1337
Justin PollaraDuke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA.
Sallie R PermarDepartment of Pediatrics, Weill Cornell Medical College, New York, New York, USA.
Kristina De ParisDepartment of Microbiology and Immunology, School of Medicine, University of North Carolina at Chapel Hillgrid.10698.36, Chapel Hill, North Carolina, USA.ORCID 0000-0001-5199-3004
University of North Carolina at Chapel Hill · USDuke Medical Center · USDuke University · USCornell University · USLouisiana State University Health Sciences Center New Orleans · USUniversity of California, Davis · US

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Deborah F. Tate · 1985 to 2026
$201.5M
National Institute on Aging (NIA) ColonyP51OD011107 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Simon J. Atkinson · 2012 to 2026
$191.5M
Virology, Immunology, and Microbiology CoreP30AI050410 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2001 to 2026
$76.9M
Social and Behavioral Sciences CoreP30AI064518 · NIAID · DUKE UNIVERSITY · PI Nwora Lance Okeke · 2005 to 2026
$50.5M
Project 2: RNA vaccination in early life to induce potent and broad HIV Env-specific antibody responsesP01AI117915 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI DE PARIS, KRISTINA, PERMAR, SALLIE R. · 2015 to 2024
$21.2M
Ruth L. Kirschstein National Research Service Award (NRSA)- T32T32AI007392 · NIAID · DUKE UNIVERSITY · PI Amy Lynn Corneli, Guido Ferrari · 1990 to 2026
$9.8M
Combined Hepatitis B and HIV-1 envelope vaccination to augment T cell help via linked recognition of unrelated antigensK01OD024877 · OD · DUKE UNIVERSITY · PI POLLARA, JUSTIN JOSEPH · 2017 to 2019
$1.0M
The Interplay of Oral Vaccines, Oral Immunity and the Oral Microbiome in InfantsR56DE026321 · NIDCR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DE PARIS, KRISTINA · 2016 to 2016
$400k
NCI NIH HHS P30 CA016086NIAID NIH HHS P01 AI117915NIAID NIH HHS P30 AI050410NIAID NIH HHS P30 AI064518NIAID NIH HHS T32 AI007392NIDCR NIH HHS R56 DE026321NIH HHS K01 OD024877NIH HHS P51 OD011107
6 · The paper itself

Abstract

Improved access to antiretroviral therapy (ART) and antenatal care has significantly reduced

Indexed as

AIDS VaccinesHIV-1HIV InfectionsSimian Immunodeficiency VirusAnimalsChildFemaleHIV AntibodiesHumansImmunoglobulin GInfectious Disease Transmission, VerticalMacaca mulattaMalePregnancyVaccinia virusViremiaAIDS VaccinesHIV AntibodiesImmunoglobulin GADCCFc-mediated antibody functionpediatric HIV vaccinerhesus macaque

Identifiers

PMID35196125
PMCPMC8865927
OpenAlexW4220906119

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.