ArticleScience advances2022
A versatile hydrogel network-repairing strategy achieved by the covalent-like hydrogen bond interaction.
Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed.
- Hydrogen sulfide-releasing hydrogels: a new perspective on clinical translation.Medical gas research · 2027Review
- Adaptive Conductive Systems: Enabling Deformable Electronics Through Engineered Materials, Circuits, and Intelligent Systems.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Self-Assembled Living Microreactors for Selective Microcystin Removal via Cascade Sieving, Adsorption and Biodegradation.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Slow-water strategy for fracture-resistant hydrogels.Nature communications · 2026Article
- A versatile and simple rectangular-topology strategy enables robust hydrogels.Nature communications · 2026Article
- Redox- and Photo-Responsive FeACS applied materials & interfaces · 2026Article
- Biomass-Derived Hydrogels for Load-Bearing Connective Tissue Repair: Integrative Reinforcement, Bio-Functional Design, and Emerging Pathways Toward Clinical Translation.Advanced healthcare materials · 2026Review
- All-in-One Underwater Quality Evaluation Metamaterial With Mechanical Robustness, Sound Attenuation, and Diffuse Reflection.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Poly(Vinyl Alcohol)-Saccharide Hydrogels with Size-Tunable Plasticization-to-Reinforcement for Flexible Sensors.Gels (Basel, Switzerland) · 2026Article
- Multifunctional NIR-Responsive Composite Hydrogel with Combinatorial Antibacterial and Regenerative Properties for Diabetic Wound Healing.Gels (Basel, Switzerland) · 2026Article
- High-Performance Gel Design for Flexible Pressure-Sensing Films in Taekwondo Applications.Gels (Basel, Switzerland) · 2026Article
- Tough hydrogels enabled by transient entanglements.Nature communications · 2026Article
- Micro-Corrugated Hydrogel Electrodes for High-Performance Biofuel Cells via Capillary Force and Ligand Exchange-Induced Metal Nanoparticle Assembly.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Molecular clustering unlocks high-performance hydrovoltaics across temperatures from -35 °C to 80 °C.Nature communications · 2026Article
- Temperature-Induced Morphological Transitions for On-Demand Detachment in Worm-Based Polymer Hydrogels.Angewandte Chemie (International ed. in English) · 2026Article
- Hydrogel adhesives for upper gastrointestinal wound healing.Theranostics · 2026Review
- Review
- A review on thermoresponsive PNIPAM hydrogels for regenerative medicine: from mechanical design to tissue adhesion.Regenerative biomaterials · 2026Review
- Ligand-channel-induced ion liberation in crowded zwitterionic hydrogel electrolyte for efficient zinc metal batteries.Nature communications · 2025Article
- Tough and tear resistant hydrogel with a sandwich mineralized structure induced by bidirectional ion migration.Nature communications · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hydrogen bond engineering is widely exploited to impart stretchability, toughness, and self-healing capability to hydrogels. However, the enhancement effect of conventional hydrogen bonds is severely limited by their weak interaction strength. In nature, some organisms tolerate extreme conditions due to the strong hydrogen bond interactions induced by trehalose. Here, we report a trehalose network-repairing strategy achieved by the covalent-like hydrogen bonding interactions to improve the hydrogels' mechanical properties while simultaneously enabling them to tolerate extreme environmental conditions and retain synthetic simplicity, which proves to be useful for various kinds of hydrogels. The mechanical properties of trehalose-modified hydrogels including strength, stretchability, and fracture toughness are substantially enhanced under a wide range of temperatures. After dehydration, the modified hydrogels maintain their hyperelasticity and functions, while the unmodified hydrogels collapse. This strategy provides a versatile methodology for synthesizing extremotolerant, highly stretchable, and tough hydrogels, which expand their potential applications to various conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.