Evidence map›Paper›PMID 35196064›Full record

Trial reportJCO oncology practice2022

Implementation of a Multisite Financial Reimbursement Program in Cancer Clinical Trials Integrated With Patient Navigation: A Pilot Randomized Clinical Trial.

Hala T Borno, Li Zhang, Sylvia Zhang, Tracy K Lin, Andrea Skafel, Elena Nieves, Dana Dornsife, Robert Johnson, Kim Rhoads, Eric Small and 1 more

Open access · hybridAbstract readRandomized Controlled Trial
In one paragraph

Trial report in JCO oncology practice, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
5.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 21 citations in OpenAlex.

  1. Trial
  2. Article
  3. Associations of symptom burden with patient-reported outcomes and clinical outcomes among early phase cancer clinical trial participants.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  4. Article
  5. Article
  6. Clinical trial-related financial considerations from Deep South-patients with breast cancer who previously declined trial participation.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Cancer survivor preferences on the timing and content of interventions to mitigate financial toxicity associated with cancer treatment.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Article
  11. Analysis of travel burden and travel support among patients treated at a comprehensive cancer center in the Southeastern United States.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Article
  12. Review
  13. Addressing transportation barriers in oncology: existing programs and new solutions.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Article
  14. Article
  15. Review
  16. Increasing Diversity of Patients in Radiation Oncology Clinical Trials.International journal of radiation oncology, biology, physics · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Hala T BornoDivision of Hematology/Oncology, Department of Medicine, University of California, San Francisco, San Francisco, CA.ORCID 0000-0002-4357-9759
Li ZhangDivision of Hematology/Oncology, Department of Medicine, University of California, San Francisco, San Francisco, CA.ORCID 0000-0002-3617-2627
Sylvia ZhangHelen Diller Family Comprehensive Cancer Center, San Francisco, CA.ORCID 0000-0001-6106-038X
Tracy K LinHelen Diller Family Comprehensive Cancer Center, San Francisco, CA.ORCID 0000-0002-6528-4564
Andrea SkafelHelen Diller Family Comprehensive Cancer Center, San Francisco, CA.
Elena NievesDivision of Oncology, Department of Medicine, University of Southern California, Los Angeles, CA.
Dana DornsifeLazarex Cancer Foundation, Danville, CA.
Robert JohnsonLazarex Cancer Foundation, Danville, CA.ORCID 0000-0003-3271-4916
Kim RhoadsDivision of Hematology/Oncology, Department of Medicine, University of California, San Francisco, San Francisco, CA.
Eric SmallDivision of Hematology/Oncology, Department of Medicine, University of California, San Francisco, San Francisco, CA.ORCID 0000-0003-3191-6268
Darcy SpicerDivision of Oncology, Department of Medicine, University of Southern California, Los Angeles, CA.
University of California, San Francisco · USLazarex Cancer Foundation · USUCSF Helen Diller Family Comprehensive Cancer Center · USUniversity of Southern California · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeCancer clinical trial participants face considerable indirect costs associated with participation, such as travel and lodging, which may contribute to poor enrollment. Here, we report the findings in IMproving Patient Access to Cancer clinical Trials, a pilot feasibility study investigating the efficacy of offering a financial reimbursement program (FRP) during a therapeutic clinical trial discussion with or without additional outreach in improving patient enrollment.

methodsStudy participants for this study were recruited at two National Cancer Institute-designated comprehensive cancer centers (CCCs) from April 8, 2019, to September 19, 2019. Eligible participants were adults with a cancer diagnosis being approached to consider enrollment in a clinical trial. Participants were randomly assigned 1:1 to receive no follow-up (usual care) or a follow-up telephone call to facilitate FRP utilization stratified by study site. The target enrollment was 132 patients, with 66 patients in each study arm. The primary outcome was the consent rate to the multisite interventional study on the FRP among participants enrolling in clinical trials.

resultsThe study had a 78% consent rate and enrolled a total of 132 participants, of whom 51% were non-White compared with 28% of CCC treatment clinical trial participants in 2019. No difference in enrollment in clinical trials between the two study arms was observed as the proportion of enrollment was 70% for both study arms. The most common reason for not enrolling in a clinical trial was due to ineligibility determined through screening procedures (75%).

conclusionThe current study observed that implementation of FRP at CCCs is feasible and serves a diverse patient population. Future studies will measure the impact of programs on overall clinical trial accrual and among racial/ethnic minorities.

Indexed as

NeoplasmsPatient NavigationAdultFeasibility StudiesHumansNational Cancer Institute (U.S.)Pilot ProjectsUnited States

Identifiers

PMID35196064
PMCPMC9191303
OpenAlexW4213440456

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.