Evidence map›Paper›PMID 35196022›Full record

ArticleScience translational medicine2022

Therapeutic efficacy of antimalarial drugs targeting DosRS signaling in

Juan Manuel Belardinelli, Deepshikha Verma, Wei Li, Charlotte Avanzi, Crystal J Wiersma, John T Williams, Benjamin K Johnson, Matthew Zimmerman, Nicholas Whittel, Bhanupriya Angala and 16 more

Open access · greenAbstract read
In one paragraph

Article in Science translational medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. The DosR regulon ofFrontiers in cellular and infection microbiology · 2025
    Article
  8. Article
  9. Review
  10. Review
  11. Review
  12. Nitric oxide-releasing prodrug for the treatment of complexAntimicrobial agents and chemotherapy · 2024
    Article
  13. Review
  14. A laboratory perspective onFrontiers in microbiology · 2024
    Review
  15. Orphan response regulator NnaR is critical for nitrate and nitrite assimilation inFrontiers in cellular and infection microbiology · 2024
    Article
  16. Article
  17. Article
  18. Article
  19. Frontiers in cellular and infection microbiology · 2023
    Article
  20. Why Matter Matters: Fast-TrackingMolecules (Basel, Switzerland) · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 8 institutions in 3 countries.

Juan Manuel BelardinelliMycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA.ORCID 0000-0003-1336-9141
Deepshikha VermaMycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA.ORCID 0000-0002-8549-6409
Wei LiMycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA.
Charlotte AvanziMycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA.ORCID 0000-0002-1062-4058
Crystal J WiersmaMycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA.
John T WilliamsDepartment of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI, USA.ORCID 0000-0002-2742-1636
Benjamin K JohnsonDepartment of Epigenetics, Van Andel Institute, Grand Rapids, MI, USA.ORCID 0000-0002-1482-1032
Matthew ZimmermanCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, USA.ORCID 0000-0002-4390-3555
Nicholas WhittelMycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA.
Bhanupriya AngalaMycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA.
Han WangCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, USA.
Victoria JonesMycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA.
Véronique DartoisCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, USA.ORCID 0000-0001-9470-5009
Vinicius C N de MouraMycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA.
Mercedes Gonzalez-JuarreroMycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA.
Camron PearceMycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA.ORCID 0000-0002-5091-0331
Alan R SchenkelDepartment of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA.ORCID 0000-0002-1603-5713
Kenneth C MalcolmDepartment of Medicine, National Jewish Health, Denver, CO, USA.
Jerry A NickDepartment of Medicine, National Jewish Health, Denver, CO, USA.ORCID 0000-0002-8910-3449
Susan A CharmanCentre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.ORCID 0000-0003-1753-8213
Timothy N C WellsMedicines for Malaria Venture, Geneva, Switzerland.ORCID 0000-0001-9796-847X
Brendan K PodellMycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA.ORCID 0000-0003-2548-8826
Jonathan L VennerstromCollege of Pharmacy, University of Nebraska Medical Center, Omaha, NE, USA.ORCID 0000-0003-0075-2336
Diane J OrdwayMycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA.ORCID 0000-0003-0003-326X
Robert B AbramovitchDepartment of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI, USA.ORCID 0000-0002-4119-4169
Mary JacksonMycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA.ORCID 0000-0002-9212-0258
Colorado State University · USHackensack Meridian Health · USMichigan State University · USNational Jewish Health · USMedicines for Malaria Venture · CHMonash University · AUUniversity of Nebraska Medical Center · USVan Andel Institute · US

Funding

Mechanisms Regulating Megakaryocyte EndomitosisR01HL080442 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI RAVID, KATYA · 2006 to 2015
$3.6M
A QTRAP 6500 LC-MS/MS System from SCIEX for high accuracy drug content analysisS10OD023524 · OD · RBHS-NEW JERSEY MEDICAL SCHOOL · PI DARTOIS, VERONIQUE · 2017 to 2017
$526k
Zeiss LSM 510 Laser Scanning MicroscopeS10RR023735 · NCRR · COLORADO STATE UNIVERSITY · PI GONZALEZ-JUARRERO, MERCEDES · 2007 to 2007
$437k
Adjunct therapeutic potential of a repurposed drug inhibiting Mycobacterium abscessus biofilm formationR21AI147326 · NIAID · COLORADO STATE UNIVERSITY · PI JACKSON, MARY · 2020 to 2021
$418k
Fluorescence Microscope for Automated Large Array Scanning and 3D imagingS10OD025127 · OD · COLORADO STATE UNIVERSITY · PI BAMBURG, JAMES R · 2018 to 2018
$188k
NCRR NIH HHS S10 RR023735NHLBI NIH HHS R01 HL080442NIAID NIH HHS R21 AI147326NIH HHS S10 OD023524NIH HHS S10 OD025127
6 · The paper itself

Abstract

A search for alternative

Indexed as

AntimalarialsMycobacterium abscessusMycobacterium Infections, NontuberculousAnimalsAnti-Bacterial AgentsMiceMicrobial Sensitivity TestsAnti-Bacterial AgentsAntimalarials

Identifiers

PMID35196022
PMCPMC8943825
OpenAlexW4213064066

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.