ArticleScience translational medicine2022
Hematopoietic cell transplantation donor-derived memory-like NK cells functionally persist after transfer into patients with leukemia.
Open access · greenAbstract read
In one paragraph
Article in Science translational medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed, 2 pooled it
8.8field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
85 citing papers in PubMed, 2 syntheses or guidelines pooled it, 111 citations in OpenAlex.
- NK cell adoptive transfer in acute myeloid leukemia: a systematic review and meta-analysis.Frontiers in immunology · 2026Pooled it
- A systematic review of the last two decades of NK cell-based clinical trials: state of the art of AML therapy.BMC cancer · 2025Pooled it
- Trial
- Advances in natural killer cell immunotherapy for hematologic malignancies.Cancer biology & therapy · 2026Review
- Harnessing Natural Killer Cells: From Neuroimmunology to Novel Therapies for Central Nervous System Diseases.MedComm · 2026Review
- Can natural killer cells cure leukemia?Leukemia · 2026Review
- Immunotherapy in acute myeloid leukemia: The antibodies, TriKEs, and CARs on the arduous road to cure.Blood reviews · 2026Review
- NT-I7, a Long-Acting Interleukin 7, Increases Lymphocyte Counts and Induces CD8+ T-cell Clonotype Expansion in Patients with Newly Diagnosed High-Grade Gliomas.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026Article
- Cultivating Functional Natural Killer Cells from Mobilized Hematopoietic Stem Cells in Heavily Pretreated Hematologic Malignancies.International journal of molecular sciences · 2026Article
- Natural killer cell immunotherapy for pancreatic cancer: Release the brakes.Molecular therapy. Oncology · 2026Article
- Exercise-mobilized lymphocytes enhance the function of cytokine-induced memory-like NK cells against myeloid leukemia.Blood advances · 2026Article
- Current development and challenges of NK cell-based immunotherapy for gastrointestinal cancers.International journal of clinical oncology · 2026Review
- HOPX is required for the generation of umbilical cord blood-derived memory-like NK cells induced by three cytokines.Frontiers in immunology · 2026Article
- Targeting innate immunity in cancer: mechanistic foundations, therapeutic vaccination, and clinical translation.Frontiers in immunology · 2026Review
- Defining the role of natural killer cells in acute myeloid leukemia through the lens of single-cell omics.Frontiers in immunology · 2026Review
- Challenges and opportunities of human iPSC-derived NK as "Off-the-shelf" cellular therapies.Journal of experimental & clinical cancer research : CR · 2025Review
- Multiplexed iPSC platform for advanced NK cell immunotherapies.Cell reports. Medicine · 2025Review
- Engineered natural killer cells for cancer therapy.Cancer cell · 2025Review
- Review
- Impact of the IL-15 superagonist N-803 on lymphatic reservoirs of HIV.JCI insight · 2025Article
25 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
40 authors at 4 institutions in 1 country.
Melissa M Berrien-ElliottDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-7319-9159
Jennifer A FoltzDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0001-9158-3464
David A Russler-GermainDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0003-1009-2247
Carly C NealDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-5700-1536
Jennifer TranDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0001-5339-1218
Margery GangDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0001-8480-6260
Pamela WongDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-6856-2603
Bryan FiskDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Celia C CubittDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0003-0037-9324
Nancy D MarinDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-2626-3349
Alice Y ZhouDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Miriam T JacobsDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-8831-7592
Mark FosterDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Timothy SchappeDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Ethan McClainDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Samantha Kersting-SchadekDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0001-9312-1802
Sweta DesaiDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-6995-3585
Patrick PenceDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-2970-9342
Michelle Becker-HapakDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0003-0323-7233
Jeremy EiseleDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Matthew MosiorDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-9704-408X
Lynne MarsalaDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Obi L GriffithDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-0843-4271
Malachi GriffithDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-6388-446X
Saad M KhanDepartment of Neurological Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-1385-2056
David H SpencerDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
John F DiPersioDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-0429-3133
Rizwan RomeeDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Geoffrey L UyDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Camille N AbboudDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-6653-3518
Armin GhobadiDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Peter WesterveltDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Keith Stockerl-GoldsteinDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-7234-1715
Mark A SchroederDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Fei WanSiteman Cancer Center, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-8311-5553
Wen-Rong LieMilliporeSigma, St. Louis, MO 68178, USA.ORCID 0000-0001-9014-1680
Patrick Soon-ShiongImmunityBio Inc., Culver City, CA 90245, USA.ORCID 0000-0002-4682-8298
Allegra A PettiDepartment of Neurological Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0001-6884-6107
Amanda F CashenDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0001-6809-4566
Todd A FehnigerDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-8705-2887
Washington University in St. Louis · USNeurological Surgery · USImmunityBio (United States) · USMoore College of Art and Design · US
Funding
Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI AIMEE S JAMES · 2001 to 2026
$128.0MWU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8MTargeting the Bone Marrow Microenvironment In Acute Lymphocytic LeukemiaP50CA171963 · NCI · WASHINGTON UNIVERSITY · PI Daniel C Link · 2013 to 2026
$31.6MPRE-AND POSTGRADUATE TRAINING IN MOLECULAR HEMATOLOGYT32HL007088 · NHLBI · WASHINGTON UNIVERSITY · PI Grant Anthony Challen, Stephen Oh · 1985 to 2026
$14.1MTRANSLATING NK CELL BIOLOGY INTO CLINICAL CANCER IMMUNOTHERAPYR01CA205239 · NCI · WASHINGTON UNIVERSITY · PI FEHNIGER, TODD A · 2017 to 2020
$2.4MInformatics tools for identification, prioritization and clinical application of neoantigensU01CA248235 · NCI · WASHINGTON UNIVERSITY · PI GRIFFITH, MALACHI · 2020 to 2022
$1.3MPostdoctoral Training Program in Genomic MedicineT32GM139799 · NIGMS · WASHINGTON UNIVERSITY · PI DICKSON, PATRICIA I · 2021 to 2025
$817kMechanism of CD8 regulation of natural killer cell biologyF30AI161318 · NIAID · WASHINGTON UNIVERSITY · PI CUBITT, CELIA CLAIRE · 2021 to 2024
$152kElucidating the role of EOMES in Memory-Like NK cell DifferentiationF31GM146361 · NIGMS · WASHINGTON UNIVERSITY · PI TRAN, JENNIFER · 2022 to 2024
$90kNCATS NIH HHS UL1 TR002345NCI NIH HHS P30 CA091842NCI NIH HHS P50 CA171963NCI NIH HHS R01 CA205239NCI NIH HHS U01 CA248235NHLBI NIH HHS T32 HL007088NIAID NIH HHS F30 AI161318NIGMS NIH HHS F31 GM146361NIGMS NIH HHS T32 GM139799
Abstract
Natural killer (NK) cells are innate lymphoid cells that eliminate cancer cells, produce cytokines, and are being investigated as a nascent cellular immunotherapy. Impaired NK cell function, expansion, and persistence remain key challenges for optimal clinical translation. One promising strategy to overcome these challenges is cytokine-induced memory-like (ML) differentiation, whereby NK cells acquire enhanced antitumor function after stimulation with interleukin-12 (IL-12), IL-15, and IL-18. Here, reduced-intensity conditioning (RIC) for
Indexed as
Hematopoietic Stem Cell TransplantationLeukemia, Myeloid, AcuteHumansImmunity, InnateInterleukin-15Killer Cells, NaturalInterleukin-15
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.