Evidence map›Paper›PMID 35196008›Full record

ArticleACS applied materials & interfaces2022

Affimer Tagged Cubosomes: Targeting of Carcinoembryonic Antigen Expressing Colorectal Cancer Cells Using

Arindam Pramanik, Zexi Xu, Shazana H Shamsuddin, Yazan S Khaled, Nicola Ingram, Thomas Maisey, Darren Tomlinson, P Louise Coletta, David Jayne, Thomas A Hughes and 2 more

Open access · hybridAbstract read
In one paragraph

Article in ACS applied materials & interfaces, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 1 pooled it
6.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Liquid crystalline system for drug delivery: structural insights, preparation techniques and translational potential.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2026
    Review
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  7. Review
  8. Review
  9. Article
  10. Review
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  12. Review
  13. Cubosomal nanoformulation increaseTherapeutic delivery · 2024
    Article
  14. Article
  15. Review
  16. Review
  17. Article
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  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Arindam PramanikSchool of Biomedical Sciences, University of Leeds, Leeds LS2 9JT, United Kingdom.ORCID https://orcid.org/0000-0002-5827-6267
Zexi XuSchool of Food Science and Nutrition, University of Leeds, Leeds LS2 9JT, United Kingdom.ORCID https://orcid.org/0000-0003-2790-0060
Shazana H ShamsuddinSchool of Biomedical Sciences, University of Leeds, Leeds LS2 9JT, United Kingdom.ORCID https://orcid.org/0000-0001-6466-2271
Yazan S KhaledSchool of Medicine, University of Leeds, Leeds LS9 7TF, United Kingdom.ORCID https://orcid.org/0000-0001-6571-3579
Nicola IngramLeeds Institute of Medical Research, St James's University Hospital, Leeds LS9 7TF, United Kingdom.ORCID https://orcid.org/0000-0001-5274-8502
Thomas MaiseySchool of Medicine, University of Leeds, Leeds LS9 7TF, United Kingdom.
Darren TomlinsonBiomedical Health Research Centre, BioScreening Technology Group, University of Leeds, Leeds LS2 9JT, United Kingdom.ORCID https://orcid.org/0000-0003-4134-7484
P Louise ColettaLeeds Institute of Medical Research, St James's University Hospital, Leeds LS9 7TF, United Kingdom.
David JayneLeeds Institute of Medical Research, St James's University Hospital, Leeds LS9 7TF, United Kingdom.ORCID https://orcid.org/0000-0002-8725-3283
Thomas A HughesSchool of Medicine, University of Leeds, Leeds LS9 7TF, United Kingdom.ORCID https://orcid.org/0000-0003-1169-3386
Arwen I I TylerSchool of Food Science and Nutrition, University of Leeds, Leeds LS2 9JT, United Kingdom.ORCID https://orcid.org/0000-0003-2116-1084
Paul A MillnerSchool of Biomedical Sciences, University of Leeds, Leeds LS2 9JT, United Kingdom.
University of Leeds · GBSt James's University Hospital · GB

Funding

Medical Research Council MR/P001483/1Wellcome Trust
6 · The paper itself

Abstract

Nanomedicines, while having been approved for cancer therapy, present many challenges such as low stability, rapid clearance, and nonspecificity leading to off-target toxicity. Cubosomes are porous lyotropic liquid crystalline nanoparticles that have shown great premise as drug delivery vehicles; however, their behavior

Indexed as

Drug Delivery SystemsAnimalsCarcinoembryonic AntigenCarrier ProteinsCell LineClick ChemistryColorectal NeoplasmsDrug LiberationHumansHydroxybutyratesLiquid CrystalsMiceMice, Inbred BALB CMice, NudeNanoparticlesPentanonesacetyl acetonateCarcinoembryonic AntigenCarrier ProteinsHydroxybutyratesPentanonesactive targetingAffimerscancercubosomeslipidslyotropic liquid crystalline nanoparticles

Identifiers

PMID35196008
PMCPMC9007418
OpenAlexW4213422398

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.