Evidence map›Paper›PMID 35195908›Full record

ArticleMedical physics2022

Effect of perfluorocarbon composition on activation of phase-changing ultrasound contrast agents.

Trevor M Mitcham, Dmitry Nevozhay, Yunyun Chen, Linh D Nguyen, Gianmarco F Pinton, Stephen Y Lai, Konstantin V Sokolov, Richard R Bouchard

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medical physics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Trevor M MitchamDepartment of Imaging Physics, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Dmitry NevozhayDepartment of Imaging Physics, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Yunyun ChenDepartment of Head and Neck Surgery, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Linh D NguyenDepartment of Imaging Physics, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Gianmarco F PintonJoint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Chapel Hill, North Carolina, USA.
Stephen Y LaiMD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, Texas, USA.
Konstantin V SokolovDepartment of Imaging Physics, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Richard R BouchardDepartment of Imaging Physics, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
The University of Texas MD Anderson Cancer Center · USThe University of Texas Health Science Center at Houston · USNorth Carolina State University · US

Funding

Targeted Phase-change Nanodroplets for Translatable Molecular Ultrasound Imaging of MicrometastasesR21CA234526 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI BOUCHARD, RICHARD R. · 2019 to 2020
$375k
NCI NIH HHS R21 CA234526NIH HHS R21CA234526
6 · The paper itself

Abstract

backgroundWhile microbubble contrast agents (MCAs) are commonly used in ultrasound (US), they are inherently limited to vascular targets due to their size. Alternatively, phase-changing nanodroplet contrast agents (PNCAs) can be delivered as nanoscale agents (i.e., small enough to extravasate), but when exposed to a US field of sufficient mechanical index (MI), they convert to MCAs, which can be visualized with high contrast using nonlinear US. PURPOSE: To investigate the effect of perfluorocarbon (PFC) core composition and presence of cholesterol in particle coatings on stability and image contrast generated from acoustic activation of PNCAs using high-frequency US suitable for clinical imaging.

methodsPNCAs with varied core compositions (i.e., mixtures of perfluoropentane [C5] and/or perfluorohexane [C6]) and two coating formulations (i.e., with and without cholesterol) were characterized and investigated for thermal/temporal stability and postactivation, nonlinear US contrast in phantom and in vivo environments. Through hydrophone measurements and nonlinear numerical modeling, MI was estimated for pulse sequences used for PNCA activation.

resultsAll PNCA compositions were characterized to have similar diameters (249-267 nm) and polydispersity (0.151-0.185) following fabrication. While PNCAs with majority C5 core composition showed higher levels of spontaneous signal (i.e., not due to US activation) in phantoms than C6-majority PNCAs, all compositions were stable during imaging experiments. When activating PNCAs with a 12.3-MHz US pulse (MI = 1.1), C6-core particles with cholesterol-free coatings (i.e., CF-C6-100 particles) generated a median contrast of 3.1, which was significantly higher (p < 0.001) than other formulations. Further, CF-C6-100 particles were activated in a murine model, generating US contrast

conclusionC6-core PNCAs can provide high-contrast US imaging with minimal nonspecific activation in phantom and in vivo environments.

Indexed as

Contrast MediaFluorocarbonsAcousticsAnimalsMiceMicrobubblesUltrasonographyContrast MediaFluorocarbonshigh-frequency ultrasoundnanodropletsperfluorocarbon contrast agentsultrasound activation

Identifiers

PMID35195908
PMCPMC9041204
OpenAlexW4212932575

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.