ArticleInfection2022
Chronic wounds in Sierra Leone: pathogen spectrum and antimicrobial susceptibility.
Article in Infection, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A systematic review and meta-analysis of the global prevalence of fluoroquinolone resistant Morganella morganii clinical isolates.Scientific reports · 2025Pooled it
- Prevalence of colistin resistance in clinical isolates ofFrontiers in microbiology · 2024Pooled it
- Bacteriological profile and multidrug resistance of Gram-negative bacteria in wound infections at a secondary healthcare facility in Ghana.BMC microbiology · 2026Article
- Formulation and Evaluation of aInfection and drug resistance · 2026Article
- Extraction and characterization of antibacterial marine polysaccharide K-Carrageenan from Kappaphycus alvarezii against multidrug-resistant wound associated bacteria.Scientific reports · 2025Article
- Suspected Buruli ulcer cases in Tonkolili District, Sierra Leone- a prospective cohort study.Infection · 2025Article
- Article
- The impact of agar depth on antimicrobial susceptibility testing by disc diffusion.Journal of medical microbiology · 2024Article
- Loop-Mediated Isothermal Amplification of DNA (LAMP) as an Alternative Method for Determining Bacteria in Wound Infections.International journal of molecular sciences · 2023Review
- Pharyngeal Communities and Antimicrobial Resistance in Pangolins in Gabon.Microbiology spectrum · 2023Article
- The Pathogen Isolates in Chronic Wound Infections in Poland.Polish journal of microbiology · 2023Article
- Relative Abundance and Detection ofMicroorganisms · 2023Review
- Research article network analysis of polymicrobial chronic wound infections in Masanga, Sierra Leone.BMC infectious diseases · 2023Article
- Mild magnetic hyperthermia is synergistic with an antibiotic treatment against dual species biofilms consisting ofInternational journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2023Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
purposeChronic wounds are frequently caused by, or super-infected with, a broad spectrum of bacteria. To guide treatment, healthcare providers need to know the bacterial spectrum and antimicrobial resistance rates to be anticipated. As these data are largely missing for Sierra Leone, we performed a microbiological study on chronic wound infections.
methodsWound swabs were analysed for bacteria using culture-based methods. Antimicrobial susceptibility testing was done with Vitek2® automated system and EUCAST clinical breakpoints. Selected resistance phenotypes were confirmed by molecular methods (e.g. mecA/C) and genotyping.
resultsOf 163 included patients, 156 (95.7%) had a positive wound culture. Pseudomonas aeruginosa (n = 75), Klebsiella pneumoniae (n = 42), Proteus mirabilis (n = 31), Staphylococcus aureus-related complex (n = 31) were predominant. Among Gram-negative rods, resistance rates were high for piperacillin/tazobactam (3-67%), cefotaxime (19-71%), and ciprofloxacin (13-60%). Among isolates of the S. aureus-related complex, 55% were methicillin resistant (CC8, PVL-negative).
conclusionThe high antimicrobial resistance rates in bacteria from chronic wounds strongly speaks against the use of empirical systemic antibiotic therapy if patients do not show signs of systemic infections, and supports the strategy of local wound care.
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