ReviewApplied biochemistry and biotechnology2022
Mannitol Production by Heterofermentative Lactic Acid Bacteria: a Review.
Review in Applied biochemistry and biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 69 citations in OpenAlex.
- A randomized, controlled trial of oral sulfate solution versus polyethylene glycol for bowel preparation for colonoscopy.BMC gastroenterology · 2025Trial
- Single-Step Production of Mannitol From Yacon Fructo-Oligosaccharides Using Fructophilic Lactic Acid Bacteria.MicrobiologyOpen · 2026Article
- Role of the Gut-Liver-Kidney Axis in Disease Manifestation and Biomarker Alterations.International journal of molecular sciences · 2026Review
- Synergistic Enhancement of Straw Hydrolysis and Lactic Acid Production inJournal of fungi (Basel, Switzerland) · 2026Article
- Article
- Rafts of change: microbial and functional dynamics in simulatedApplied and environmental microbiology · 2026Article
- The Comparison of Mannitol Prepared with Different PVP: Crystal Form, Morphology, Functional Properties, andACS omega · 2026Article
- Article
- Apilactobacillus kunkeei as a promising fermentation candidate for reducing free sugars in fruit juices.BMC microbiology · 2026Article
- Production of mannitol from molasses and Jerusalem artichoke tubers at elevated temperatures using engineeredCurrent research in food science · 2026Article
- Lactobacillus salivary LSbg3 is a Potential Food Probiotic Having Excellent Anti-pathogen Effect That Might Improve Antibiotic-Resistant Diarrhea in Dogs.Probiotics and antimicrobial proteins · 2026Article
- Changes in nutritional and volatile composition of peach puree as affected by fermentation with differentFood chemistry: X · 2026Article
- Bioprotective and Technological Roles of Lactic Acid Bacteria in Reduced-Sodium Fermented Sausages.Foods (Basel, Switzerland) · 2025Review
- Characteristics of Novel Fermented Cloudy Fruit Juices Produced UsingMolecules (Basel, Switzerland) · 2025Article
- Beyond Sugar: A Holistic Review of Sweeteners and Their Role in Modern Nutrition.Foods (Basel, Switzerland) · 2025Review
- Sugar alcohols in plants: implications for enhancing tree seedlings drought tolerance and production strategies.BMC plant biology · 2025Review
- Non-targeted metabolomics reveals the effects of fermented methods on the flavor, quality, and metabolites of whipping cream.Food chemistry: X · 2025Article
- Regulation of Sugar Metabolism During Fermentation of Brewers' Spent Grain by Leuconostoc pseudomesenteroides DSM20193.Microbial biotechnology · 2025Article
- Biosynthesis and metabolic engineering of natural sweeteners.AMB Express · 2025Review
- Fermentation dynamics of millet beverages: Microbial interactions, nutritional enhancements, and health implications.Food chemistry: X · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Obesity, diabetes, and other cardiovascular diseases are directly related to the high consumption of processed sugars with high caloric content. The current food industry has novel trends related to replacing highly caloric sugars with non-caloric or low-calorie sweeteners. Mannitol, a polyol, represents a suitable substitute because it has a low caloric content and does not induce a glycemic response, which is crucial for diabetic people. Consequently, this polyol has multiple applications in the food, pharmaceutical, and medicine industries. Mannitol can be produced by plant extraction, chemical or enzymatic synthesis, or microbial fermentation. Different in vitro processes have been developed regarding enzymatic synthesis to obtain mannitol from fructose, glucose, or starch-derived substrates. Various microorganisms such as yeast, fungi, and bacteria are applied for microbial fermentation. Among them, heterofermentative lactic acid bacteria (LAB) represent a reliable and feasible alternative due to their metabolic characteristics. In this regard, the yield and productivity of mannitol depend on the culture system, the growing conditions, and the culture medium composition. In situ mannitol production represents a novel approach to decrease the sugar content in food and beverages. Also, genetic engineering offers an interesting option to obtain mannitol-producing strains. This review presents and discusses the most significant advances that have been made in the mannitol production through fermentation by heterofermentative LAB, including the pertinent and critical analysis of culture conditions considering broth composition, reaction systems, and their effects on productivities and yields.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.