Evidence map›Paper›PMID 35195798›Full record

Trial reportHernia : the journal of hernias and abdominal wall surgery2022

Is absorbable mesh useful in preventing parastomal hernia after emergency surgery? The PARTHENOPE study.

F Pizza, D D'Antonio, F S Lucido, P Del Rio, C Dell'Isola, L Brusciano, S Tolone, L Docimo, C Gambardella

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Hernia : the journal of hernias and abdominal wall surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04436887 (Prophylactic Sub-lay Non-absorbable Mesh Following Emergent Midline Laparotomy Clean/Contaminated Field), which is not on this map. Cited by 10 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 3 pooled it
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04436887 nacompletednot on this map

Prophylactic Sub-lay Non-absorbable Mesh Following Emergent Midline Laparotomy Clean/Contaminated Field: Early Results of a Randomized Double-blind Prospective Trial: PROMETHEUS

TypeinterventionalSponsorFrancesco PizzaRan2016 to 2020Enrolled200ConditionsIncisional Hernia, Wound InfectionArmspositioning of polypropylene strips for prophylactic purposes in closing the middle laparotomies to prevent the incisional hernia
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 3 syntheses or guidelines pooled it, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

F PizzaDepartment of Surgery, Aslnapoli2nord - Hospital "A. Rizzoli", Naples, Italy. Francesco_pizza@libero.it.ORCID http://orcid.org/0000-0001-9785-4405
D D'AntonioDepartment of Surgery, Aslnapoli2nord - Hospital "A. Rizzoli", Naples, Italy.
F S LucidoDivision of General, Mininvasive and Bariatric Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy.
P Del RioIstituto Nazionale dei Tumori IRCS "Fondazione Pascale", Naples, Italy.
C Dell'IsolaAORN "dei Colli" Monaldi-Cotugno-CTO Department of Infectious Diseases-Hepatologic Address, Rome, Italy.
L BruscianoDivision of General, Mininvasive and Bariatric Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy.
S ToloneDivision of General, Mininvasive and Bariatric Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy.
L DocimoDivision of General, Mininvasive and Bariatric Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy.
C GambardellaDivision of General, Mininvasive and Bariatric Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy.
University of Campania "Luigi Vanvitelli" · ITIstituto Nazionale Tumori IRCCS "Fondazione G. Pascale" · ITOrthopedic Institute · USOspedale Monaldi · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeColostomy is a frequent event in oncological or inflammatory bowel diseases. Its related morbidity includes retraction, infection and parastomal hernia (PH), which is a quite common late complication. Several surgical options are available for PH repair, the majority including mesh. However, results are often disappointing with relevant recurrence rates, up to 33%. The study aim was to assess the feasibility and effectiveness of prophylactic biosynthetic mesh (BIO-A

methodsPatients were clinically followed up at 3, 6, and 12 months and received a CT scan at 6 and 12 months. The postoperative morbidity and wound events were also evaluated.

results55 patients receiving conventional colostomy considered as Control Group and 55 patients receiving BIO-A mesh supported colostomy (Mesh Group) were included in the study. At 12 months, the incidence of PH was 9 (12.7%) and 24 (43.6%) in the Mesh Group and Control Group, respectively (p < 0.05). Postoperative morbidity was similar between Mesh Group and Control Group (7 [12.7%] vs 4 [7.3%], respectively; p = 0.340). The multivariable analysis showed that not using a mesh (p = 0.042), age > 70 years (p = 0.041), diabetes (p < 0.001), colon dilation > 7 cm (p < 0.0001) and COPD (p = 0.009) were all related with postoperative PH.

conclusionsThe prophylactic BIO-A mesh positioning during colostomy is an effective procedure reducing PH incidence at a 1 years follow-up guaranteeing low postoperative morbidity. STUDY DATASET IS AVAILABLE ON CLINICALTRIALS. GOV ID: NCT04436887.

Indexed as

Incisional HerniaPostoperative ComplicationsSurgical MeshAgedColostomyHerniorrhaphyHumansProspective StudiesSurgical StomasAbsorbable meshHartmann's urgent procedureParastomal hernia prevention

Identifiers

PMID35195798
OpenAlexW4213204509

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.