Evidence map›Paper›PMID 35195728›Full record

ArticleJournal of cognitive neuroscience2022

Effects of Multisession Prefrontal Transcranial Direct Current Stimulation on Long-term Memory and Working Memory in Older Adults.

Jacky Au, Rachel N Smith-Peirce, Elena Carbone, Austin Moon, Michelle Evans, John Jonides, Susanne M Jaeggi

Open access · bronzeAbstract read
In one paragraph

Article in Journal of cognitive neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Jacky AuUniversity of California, Irvine.
Rachel N Smith-PeirceUniversity of California, Irvine.
Elena CarboneUniversity of Padova.
Austin MoonUniversity of California, Riverside.ORCID 0000-0001-8295-9669
Michelle EvansUniversity of Michigan.
John JonidesUniversity of Michigan.
Susanne M JaeggiUniversity of California, Irvine.
University of California, Irvine · USUniversity of Michigan · USUniversity of California, Riverside · USUniversity of Padua · IT

Funding

University of California Health Participation in the National COVID Cohort Collaborative (N3C)UL1TR001414 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M, VILAIN, ERIC J. · 2015 to 2023
$35.1M
NRSA Training CoreTL1TR001415 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI CAIOZZO, VINCENT JAMES, HEAD, ELIZABETH · 2015 to 2023
$4.2M
Working Memory Training in Older AdultsR01AG049006 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI JAEGGI, SUSANNE M · 2015 to 2018
$2.5M
Cognitive Training and Brain Plasticity - Towards an Understanding of Mediators and ModeratorsK02AG054665 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI JAEGGI, SUSANNE M · 2017 to 2021
$806k
National Science Foundation 1658268NCATS NIH HHS TL1 TR001415NCATS NIH HHS UL1 TR001414NIA NIH HHS 1K02AG054665NIA NIH HHS K02 AG054665NIA NIH HHS R01 AG049006
6 · The paper itself

Abstract

Transcranial direct current stimulation (tDCS) is a noninvasive form of electrical brain stimulation popularly used to augment the effects of working memory (WM) training. Although success has been mixed, some studies report enhancements in WM performance persisting days, weeks, or even months that are actually more reminiscent of consolidation effects typically observed in the long-term memory (LTM) domain, rather than WM improvements per se. Although tDCS has been often reported to enhance both WM and LTM, these effects have never been directly compared within the same study. However, given their considerable neural and behavioral overlap, this is a timely comparison to make. This study reports results from a multisession intervention in older adults comparing active and sham tDCS over the left dorsolateral pFC during training on both an n-back WM task and a word learning LTM task. We found strong and robust effects on LTM, but mixed effects on WM that only emerged for those with lower baseline ability. Importantly, mediation analyses showed an indirect effect of tDCS on WM that was mediated by improvements in consolidation. We conclude that tDCS over the left dorsolateral pFC can be used as an effective intervention to foster long-term learning and memory consolidation in aging, which can manifest in performance improvements across multiple memory domains.

Indexed as

Memory ConsolidationTranscranial Direct Current StimulationAgedHumansLearningMemory, Long-TermMemory, Short-Term

Identifiers

PMID35195728
PMCPMC9836784
OpenAlexW4213153986

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.