ArticleAnnals of behavioral medicine : a publication of the Society of Behavioral Medicine2023
Systemic Inflammation Contributes to the Association Between Childhood Socioeconomic Disadvantage and Midlife Cardiometabolic Risk.
Article in Annals of behavioral medicine : a publication of the Society of Behavioral Medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Childhood socioeconomic status and changes in biological aging across mid-to-later life.Social science & medicine (1982) · 2026Article
- Association Between Socioeconomic Status and Mortality Risk in CKM Stage 0-3 Patients: Analysis of Inflammatory Mediation.Cardiology research and practice · 2026Article
- Association between social determinants of health and erectile dysfunction: insights from a nationally representative US sample.Translational andrology and urology · 2025Article
- Toward precision interventions and metrics of inflammaging.Nature aging · 2025Review
- Childhood Family Income and Adult Cardiovascular Health: Indirect Effects Through Childhood Neighborhood Socioeconomic Advantages and Disadvantages in a Prospective Sample of Young Men.Journal of the American Heart Association · 2025Article
- Long-term effects of health during childhood on depressive symptoms in later life: evidence from a nationally representative survey in China.BMC public health · 2025Article
- Biological embodiment of educational attainment and future risk of breast cancer: findings from a French prospective cohort.BMJ open · 2025Article
- Association between body roundness index and phenoage acceleration among US adults.Frontiers in public health · 2025Article
- Community Socioeconomic Disadvantage Relates to White Matter Hyperintensity Burden in Mid-to-Late Life Adults.Biopsychosocial science and medicineArticle
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Authors and funding
7 authors.
Funding
Abstract
backgroundChildhood socioeconomic disadvantage is associated with increased risk for chronic inflammation and cardiometabolic disease at midlife. PURPOSE: As it is presently unknown whether inflammation mediates the relationship between childhood socioeconomic status (SES) and adulthood cardiometabolic risk, we investigated associations between retrospectively reported childhood SES, circulating levels of inflammatory markers, and a latent construct of cardiometabolic risk in midlife adults.
methodsParticipants were 1,359 healthy adults aged 30-54 (Adult Health and Behavior Iⅈ 52% women, 17% Black) who retrospectively reported childhood SES (parental education, occupational grade). Measures included plasma interleukin (IL)-6, C-reactive protein (CRP), and cardiometabolic risk factors. Structural equation modeling was conducted, with cardiometabolic risk modeled as a second-order latent variable with adiposity, blood lipids, glucose control, and blood pressure as first-order components.
resultsLower childhood SES was associated with greater risk for cardiometabolic disease at midlife (β = -0.08, CI[-0.04, -0.01], p = .01) in models adjusted for demographics, but this association was attenuated in models that adjusted for adulthood SES and health behaviors. In fully-adjusted models, the relationship between lower childhood SES and adult cardiometabolic risk was partially explained by higher circulating levels of CRP (β = -0.05, CI[-0.02, -0.01], p = .001), but not by IL-6. In an exploratory model, lower adulthood SES was also found to independently contribute to the association between childhood SES and adult cardiometabolic risk (β = -0.02, CI[-0.01, -0.001], p = .02).
conclusionsThe current study provides initial evidence that systemic inflammation may contribute to childhood socioeconomic disparities in cardiometabolic risk in midlife. Future work would benefit from prospective investigation of these relationships.
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