Evidence map›Paper›PMID 35195533›Full record

ArticleJMIR research protocols2022

The Effects of Modified Intermittent Fasting in Psoriasis (MANGO): Protocol for a Two-Arm Pilot Randomized Controlled Open Cross-over Study.

Lynda Grine, Niels Hilhorst, Nathalie Michels, Souheila Abbeddou, Stefaan De Henauw, Jo Lambert

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JMIR research protocols, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04418791 (Modified Intermittent Fasting in Psoriasis Trial), which is not on this map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04418791 nacompletednot on this map

Modified Intermittent Fasting in Psoriasis Trial: a Randomized Controlled Open Crossover Clinical Trial to Investigate the Effects of a Dietary Intervention on the Gut-skin Axis in Patients with Psoriasis

TypeinterventionalSponsorUniversity Hospital, GhentRan2020 to 2022Enrolled24ConditionsPsoriasis Vulgaris, PsoriasisArmsModified Intermittent Fasting followed by Regular Diet, Regular Diet followed by Modified Intermittent Fasting
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Lynda GrineDermatology Research Unit, Department of Head and Skin, Ghent University, Ghent, Belgium.ORCID https://orcid.org/0000-0002-7546-4454
Niels HilhorstDermatology Research Unit, Department of Head and Skin, Ghent University, Ghent, Belgium.ORCID https://orcid.org/0000-0002-5355-6235
Nathalie MichelsDepartment of Public Health and Primary Care, Ghent University, Ghent, Belgium.ORCID https://orcid.org/0000-0002-3069-7254
Souheila AbbeddouDepartment of Public Health and Primary Care, Ghent University, Ghent, Belgium.ORCID https://orcid.org/0000-0002-1363-0170
Stefaan De HenauwDepartment of Public Health and Primary Care, Ghent University, Ghent, Belgium.ORCID https://orcid.org/0000-0003-4141-5432
Jo LambertDermatology Research Unit, Department of Head and Skin, Ghent University, Ghent, Belgium.ORCID https://orcid.org/0000-0001-5303-9310
Ghent University · BEGhent University Hospital · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPsoriasis is a complex disease associated with multiple comorbidities, including metabolic syndrome and leaky gut syndrome. Dietary lifestyle interventions have been reported to affect the disease in terms of lesional severity. It remains unclear how diets affect these comorbidities and the general health in psoriasis patients. Modified intermittent fasting (MIF) on 2 nonconsecutive days has shown beneficial effects on metabolic parameters. A significant advantage of MIF over the currently investigated dietary changes is its feasibility.

objectiveHere, we aim to study the effects of MIF on skin, gut, and metabolic health in psoriasis patients.

methodsA 2-arm pilot randomized controlled open cross-over study will be performed in 24 patients with psoriasis. Patients will be randomized 1:1 to either start with 12 weeks of MIF and go on a subsequent regular diet for another 12 weeks or start with 12 weeks of regular diet and do subsequent MIF for 12 weeks. The following parameters will be assessed: demographics, disease phenotype, medical and familial history, psoriasis severity, dermatology-specific and general quality of life, nutritional and physical habits, mental and intestinal health, intestinal and cutaneous integrity, inflammatory and metabolic markers, and satisfaction.

resultsA total of 24 participants have been enrolled in the study. The final visit is foreseen for June 2021.

conclusionsThe aim is to uncover the effects of MIF on psoriasis severity and gut health integrity through clinical and molecular investigation. More precisely, we want to map the evolution of the different markers, such as psoriasis severity, permeability, and inflammation, in response to MIF as compared to a regular diet,. Understanding how dietary lifestyles can affect epithelial lineages, such as the skin and gut, will greatly improve our understanding of the development of psoriasis and may offer a nonpharmacological venue for treatments.

trial registrationClinicalTrials.gov NCT04418791; https://clinicaltrials.gov/ct2/show/NCT04418791. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/26405.

Indexed as

dietary interventiongut-skin axisintermittent fastingleaky gutpsoriasis

Identifiers

PMID35195533
PMCPMC8908196
OpenAlexW3116102740

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.