ArticleJournal of feline medicine and surgery2022
Serum concentrations of gabapentin in cats with chronic kidney disease.
Article in Journal of feline medicine and surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- 2026 iCatCare consensus guidelines on the diagnosis and management of chronic kidney disease in cats.Journal of feline medicine and surgery · 2026Guideline
- Update on Treatment of Feline Infectious Peritonitis: European Advisory Board on Cat Diseases (ABCD) Guidelines.Viruses · 2026Review
- Caregivers' perspectives on feline chronic kidney disease in Portugal: a questionnaire-based study.Journal of feline medicine and surgery · 2025Article
- Clinical therapeutics in feline medicine: updates for old and new drugs.Journal of feline medicine and surgery · 2025Review
- The Effect of Gabapentin on the Efficiency of a Desensitization-Counter-Conditioning Claw-Trimming Protocol for Cats with Healthcare Phobias: A Double-Blind, Placebo-Controlled Crossover Trial.Animals : an open access journal from MDPI · 2025Article
- Effect of oral administration of trazodone on physiological and echocardiographic variables in cats.Journal of feline medicine and surgery · 2025Article
- Self-reported cat-friendly practices and attitudes of German, French and Swiss veterinarians.Journal of feline medicine and surgery · 2025Article
- Tools for the Approach of Fear, Anxiety, and Stress in the Domestic Feline: An Update.Veterinary medicine international · 2025Review
- Evaluation of the sedative properties of oral trazodone, gabapentin or their combination in healthy cats.Journal of feline medicine and surgery · 2024Article
- Effects of Gabapentin on the Treatment of Behavioral Disorders in Dogs: A Retrospective Evaluation.Animals : an open access journal from MDPI · 2024Article
- Neuropathic pain in cats: Mechanisms and multimodal management.Journal of feline medicine and surgery · 2024Review
- Assessment of the effect of gabapentin on blood pressure in cats with and without chronic kidney disease.Journal of feline medicine and surgery · 2024Article
- 2023 AAFP/IAAHPC feline hospice and palliative care guidelines.Journal of feline medicine and surgery · 2023Review
- Gabapentin: Clinical Use and Pharmacokinetics in Dogs, Cats, and Horses.Animals : an open access journal from MDPI · 2023Review
- Feline Stress Management During air Travel: A Multimodal Approach.Journal of feline medicine and surgery · 2023Review
- 2022 AAFP/ISFM Cat Friendly Veterinary Interaction Guidelines: Approach and Handling Techniques.Journal of feline medicine and surgery · 2022Article
- Presumed gabapentin-induced myoclonus in two cats.JFMS open reportsArticle
- Evaluation of gabapentin administration on neurologic examination in 2 different age groups of healthy cats.Journal of veterinary internal medicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesThe purpose of this study was to assess serum concentrations of gabapentin in cats with chronic kidney disease (CKD) vs clinically healthy cats.
methodsFive healthy cats were enrolled in a pharmacokinetic study. A single 20 mg/kg dose of gabapentin was administered orally and blood was obtained at 0, 0.25, 0.5, 1, 1.5, 2, 3, 4, 8, 12, 24 and 36 h via a jugular catheter. Serum gabapentin concentrations were measured using liquid chromatography coupled to tandem mass spectrometry. Non-compartmental pharmacokinetic analysis was performed. The same five healthy cats plus 25 cats with stable International Renal Interest Society stage 2 (n = 14) and 3 (n = 11) CKD were enrolled in a limited sampling study. Cats in both groups received a single 10 mg/kg dose of gabapentin, and serum gabapentin concentrations and compliance scores were obtained 3 and 8 h post-administration.
resultsCats with CKD had significantly higher dose-normalized serum gabapentin concentrations than normal cats at 3 h ( CONCLUSIONS AND RELEVANCE: Cats with CKD that received 10 mg/kg of gabapentin had significantly higher dose-normalized serum concentrations than normal cats that received 20 mg/kg, supporting the need to dose-reduce in this patient population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.