Evidence map›Paper›PMID 35195446›Full record

ReviewClinical microbiology reviews2022

Clinical and Public Health Implications of Human T-Lymphotropic Virus Type 1 Infection.

Nicolas Legrand, Skye McGregor, Rowena Bull, Sahar Bajis, Braulio Mark Valencia, Amrita Ronnachit, Lloyd Einsiedel, Antoine Gessain, John Kaldor, Marianne Martinello

Abstract readReview
In one paragraph

Review in Clinical microbiology reviews, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. HTLV-1-associated diseases: a systematic review.Revista do Instituto de Medicina Tropical de Sao Paulo · 2026
    Pooled it
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Epidemiology and Clinical Outcomes of HTLV-1: A Comprehensive Narrative Review of Endemic and Nonendemic Regions.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2026
    Review
  12. Review
  13. Article
  14. Article
  15. A Framework for Evaluation of New Processing Technologies in Human Milk Banking.Comprehensive reviews in food science and food safety · 2025
    Review
  16. Article
  17. Article
  18. Article
  19. Efgartigimod Combined With Steroid Treatment for HAM/TSP: A Case Report.Annals of clinical and translational neurology · 2025
    Article
  20. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nicolas LegrandKirby Institute, UNSW Sydney, Sydney, New South Wales, Australia.ORCID 0000-0002-1404-3592
Skye McGregorKirby Institute, UNSW Sydney, Sydney, New South Wales, Australia.
Rowena BullKirby Institute, UNSW Sydney, Sydney, New South Wales, Australia.
Sahar BajisKirby Institute, UNSW Sydney, Sydney, New South Wales, Australia.
Braulio Mark ValenciaKirby Institute, UNSW Sydney, Sydney, New South Wales, Australia.
Amrita RonnachitRoyal Prince Alfred Hospital, Sydney, New South Wales, Australia.
Lloyd EinsiedelCentral Australian Health Service, Alice Springs, Northern Territory, Australia.
Antoine GessainInstitut Pasteurgrid.428999.7, Epidemiology and Physiopathology of Oncogenic Viruses Unit, Paris, France.
John KaldorKirby Institute, UNSW Sydney, Sydney, New South Wales, Australia.
Marianne MartinelloKirby Institute, UNSW Sydney, Sydney, New South Wales, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human T-lymphotropic virus type 1 (HTLV-1) is estimated to affect 5 to 10 million people globally and can cause severe and potentially fatal disease, including adult T-cell leukemia/lymphoma (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). The burden of HTLV-1 infection appears to be geographically concentrated, with high prevalence in discrete regions and populations. While most high-income countries have introduced HTLV-1 screening of blood donations, few other public health measures have been implemented to prevent infection or its consequences. Recent advocacy from concerned researchers, clinicians, and community members has emphasized the potential for improved prevention and management of HTLV-1 infection. Despite all that has been learned in the 4 decades following the discovery of HTLV-1, gaps in knowledge across clinical and public health aspects persist, impeding optimal control and prevention, as well as the development of policies and guidelines. Awareness of HTLV-1 among health care providers, communities, and affected individuals remains limited, even in countries of endemicity. This review provides a comprehensive overview on HTLV-1 epidemiology and on clinical and public health and highlights key areas for further research and collaboration to advance the health of people with and at risk of HTLV-1 infection.

Indexed as

HTLV-I InfectionsHuman T-lymphotropic virus 1Leukemia-Lymphoma, Adult T-CellParaparesis, Tropical SpasticAdultHumansPublic Healthclinical methodsclinical therapeuticsdiagnosticsepidemiologyhuman T-cell leukemia virusoncogenic viruspathogenesispublic healthsexually transmitted diseasesvirology

Identifiers

PMID35195446
PMCPMC8941934

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.