Evidence map›Paper›PMID 35195401›Full record

ArticleJournal of medicinal chemistry2022

Structure-Based Design of a Chemical Probe Set for the 5-HT

Anat Levit Kaplan, Ryan T Strachan, Joao M Braz, Veronica Craik, Samuel Slocum, Thomas Mangano, Vanessa Amabo, Henry O'Donnell, Parnian Lak, Allan I Basbaum and 2 more

Abstract read
In one paragraph

Article in Journal of medicinal chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Psychedelics: preclinical insights provide directions for future research.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Anat Levit KaplanDepartment of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California 94143, United States.
Ryan T StrachanDepartment of Pharmacology, School of Medicine, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina 27514, United States.
Joao M BrazDepartment of Anatomy, University of California, San Francisco, San Francisco, California 94143, United States.
Veronica CraikDepartment of Anatomy, University of California, San Francisco, San Francisco, California 94143, United States.
Samuel SlocumNational Institute of Mental Health Psychoactive Drug Screening Program, School of Medicine, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina 27514, United States.
Thomas ManganoNational Institute of Mental Health Psychoactive Drug Screening Program, School of Medicine, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina 27514, United States.
Vanessa AmaboNational Institute of Mental Health Psychoactive Drug Screening Program, School of Medicine, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina 27514, United States.
Henry O'DonnellDepartment of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California 94143, United States.
Parnian LakDepartment of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California 94143, United States.
Allan I BasbaumDepartment of Anatomy, University of California, San Francisco, San Francisco, California 94143, United States.
Bryan L RothDepartment of Pharmacology, School of Medicine, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina 27514, United States.ORCID 0000-0002-0561-6520
Brian K ShoichetDepartment of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California 94143, United States.ORCID 0000-0002-6098-7367

Funding

Illuminating the Druggable GPCR-omeU24DK116195 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ROTH, BRYAN L., SHOICHET, BRIAN K · 2017 to 2022
$14.3M
Development and Testing of New Computational Methods for Ligand Discovery and MechanismR35GM122481 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Brian K Shoichet · 2017 to 2026
$8.5M
From the spinal cord to the brain: Neurology of the pain and itch neuronsR35NS097306 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BASBAUM, ALLAN I. · 2017 to 2024
$7.2M
Molecular Details of Psychoactive Drug ActionsR01MH112205 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Bryan L. Roth, Brian K Shoichet · 2017 to 2026
$6.1M
Integrated discovery of tool molecules for illuminating the brain GPCRomeK01MH109943 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI STRACHAN, RYAN THOMAS · 2016 to 2019
$485k
NIDDK NIH HHS U24 DK116195NIGMS NIH HHS R35 GM122481NIMH NIH HHS K01 MH109943NIMH NIH HHS R01 MH112205NINDS NIH HHS R35 NS097306
6 · The paper itself

Abstract

The 5-HT

Indexed as

SerotoninSerotonin AntagonistsHumansLigandsPainReceptors, SerotoninLigandsReceptors, SerotoninSerotoninSerotonin Antagonists

Identifiers

PMID35195401
PMCPMC9116900

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.