ArticleArquivos de neuro-psiquiatria2022
Coexistence of restless legs syndrome and multiple sclerosis aggravates anxiety and depression.
Article in Arquivos de neuro-psiquiatria, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.
- Associations of anxiety and depression with restless leg syndrome: a systematic review and meta-analysis.Frontiers in neurology · 2024Pooled it
- Neuropathic pain versus restless legs syndrome: distinct and combined effects on balance and walking performance in multiple sclerosis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Understanding Depression in People Living with Multiple Sclerosis: A Narrative Review of Recent Literature.Neurology and therapy · 2025Review
- Fatigue, Insomnia, and Disability as Independent Predictors of Depressive Symptoms in Multiple Sclerosis: A Prospective Observational Study.Sisli Etfal Hastanesi tip bulteni · 2025Article
- Restless legs syndrome in multiple sclerosis: uncovering prevalence and clinical aspects.Sleep & breathing = Schlaf & Atmung · 2024Article
- Depression and anxiety in multiple sclerosis. Review of a fatal combination.Journal of neural transmission (Vienna, Austria : 1996) · 2024Review
Corrections and comments
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Authors and funding
21 authors at 13 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAmong the comorbidities that accompany multiple sclerosis (MS), restless legs syndrome (RLS) is one of the most common. Anxiety and depression are common psychological comorbidities that impact the quality of life of patients with MS (PwMS), as well as patients with RLS.
objectiveTo investigate the psychiatric burden of MS and RLS coexistence, we conducted a nationwide, multicenter and cross-sectional survey.
methodsParticipants were assessed by using demographic and clinical parameters along with the Hamilton Anxiety and Hamilton Depression Scales (HAM-A and HAM-D).
resultsOut of the 1,068 participants, 173 (16.2%) were found to have RLS [RLS(+)] and 895 (83.8%) did not [RLS(-)]. The mean scores for HAM-A and HAM-D were significantly higher among RLS(+) subjects than among RLS(-) subjects (p<0.001 for all variables).
conclusionsAccording to our data, the presence of RLS in PwMS may increase the occurrence of both anxiety and depression symptoms. Awareness and treatment of RLS in PwMS could possibly reduce the symptoms of psychiatric comorbidities originating from RLS.
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