Evidence map›Paper›PMID 35195068›Full record

ArticleeLife2022

Spatial transcriptomic and single-nucleus analysis reveals heterogeneity in a gigantic single-celled syncytium.

Tobias Gerber, Cristina Loureiro, Nico Schramma, Siyu Chen, Akanksha Jain, Anne Weber, Anne Weigert, Malgorzata Santel, Karen Alim, Barbara Treutlein and 1 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Coexistence of trapped and flow-transported nuclei enables fast pigeon post communication across multinucleated cell.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. A mathematical model to predict network growth inJournal of the Royal Society, Interface · 2025
    Article
  7. Size-dependent self-avoidance enables superdiffusive migration in macroscopic unicellulars.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  8. Review
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Tobias Gerber *Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany.ORCID 0000-0001-8456-5495
Cristina Loureiro *Department of Biosystems Science and Engineering, ETH Zürich, Basel, Switzerland.
Nico Schramma *Max Planck Institute for Dynamics and Self-Organization, Göttingen, Germany.
Siyu ChenMax Planck Institute for Dynamics and Self-Organization, Göttingen, Germany.
Akanksha JainDepartment of Biosystems Science and Engineering, ETH Zürich, Basel, Switzerland.
Anne WeberMax Planck Institute for Dynamics and Self-Organization, Göttingen, Germany.
Anne WeigertMax Planck Institute for Evolutionary Anthropology, Leipzig, Germany.
Malgorzata SantelDepartment of Biosystems Science and Engineering, ETH Zürich, Basel, Switzerland.
Karen AlimMax Planck Institute for Dynamics and Self-Organization, Göttingen, Germany.ORCID 0000-0002-2527-5831
Barbara TreutleinMax Planck Institute for Evolutionary Anthropology, Leipzig, Germany.ORCID 0000-0002-3299-5597
J Gray CampMax Planck Institute for Evolutionary Anthropology, Leipzig, Germany.ORCID 0000-0003-3295-1225
ETH Zurich · CHMax Planck Institute for Dynamics and Self-Organization · DEMax Planck Institute for Evolutionary Anthropology · DERoche (Switzerland) · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In multicellular organisms, the specification, coordination, and compartmentalization of cell types enable the formation of complex body plans. However, some eukaryotic protists such as slime molds generate diverse and complex structures while remaining in a multinucleate syncytial state. It is unknown if different regions of these giant syncytial cells have distinct transcriptional responses to environmental encounters and if nuclei within the cell diversify into heterogeneous states. Here, we performed spatial transcriptome analysis of the slime mold

Indexed as

Single-Cell AnalysisTranscriptomeGene Expression RegulationGiant CellsPhysarum polycephalumRNA-Seqcell biologygeneticsgenomicsPhysarum polycephalumSingle-nucleus RNA-seqSpatial transcriptomicssyncytium

Identifiers

PMID35195068
PMCPMC8865844
OpenAlexW4213053463

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.