Evidence map›Paper›PMID 35195023›Full record

Observational studyBiomarkers in medicine2022

Decreased circulating dipeptidyl peptidase-4 enzyme activity is prognostic for severe outcomes in COVID-19 inpatients.

Ákos Nádasdi, György Sinkovits, Ilona Bobek, Botond Lakatos, Zsolt Förhécz, Zita Z Prohászka, Marienn Réti, Miklós Arató, Gellért Cseh, Tamás Masszi and 5 more

Open access · greenAbstract readObservational Study
In one paragraph

Observational study in Biomarkers in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. ACE2, ACE, DPPIV, PREP and CAT L enzymatic activities in COVID-19: imbalance of ACE2/ACE ratio and potential RAAS dysregulation in severe cases.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2023
    Article
  6. Review
  7. Article
  8. Rebound increase in circulating dipeptidyl peptidase 4 (DPP4) enzyme activity after acute COVID-19.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  9. Reply to Firneisz: "Rebound increase in circulating dipeptidyl peptidase-4 (DPP4) enzyme activity after acute Covid-19".Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  10. Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Ákos NádasdiRamgen Plc., Budapest, H-1126, Hungary.ORCID 0000-0002-7016-6474
György SinkovitsDepartment of Internal Medicine & Haematology, Research Laboratory, Semmelweis University, Budapest, H-1088, Hungary.ORCID 0000-0002-5355-7318
Ilona BobekDepartment of Anaesthesiology & Intensive Care Medicine, Central Hospital of Southern Pest, National Institute of Haematology & Infectious Diseases, Budapest, H-1097, Hungary.ORCID 0000-0003-2187-4666
Botond LakatosDepartment of Infectology, Central Hospital of Southern Pest, National Institute of Haematology & Infectious Diseases, Budapest, H-1097, Hungary.ORCID 0000-0001-7276-7639
Zsolt FörhéczDepartment of Internal Medicine & Haematology, Semmelweis University, Budapest, H-1088, Hungary.ORCID 0000-0001-5123-4593
Zita Z ProhászkaDepartment of Internal Medicine & Haematology, Research Laboratory, Semmelweis University, Budapest, H-1088, Hungary.
Marienn RétiDepartment of Haematology & Stem Cell Transplantation, Central Hospital of Southern Pest, National Institute of Haematology & Infectious Diseases, Budapest, H-1097, Hungary.
Miklós AratóRamgen Plc., Budapest, H-1126, Hungary.ORCID 0000-0002-7576-5513
Gellért CsehRamgen Plc., Budapest, H-1126, Hungary.
Tamás MassziDepartment of Internal Medicine & Haematology, Semmelweis University, Budapest, H-1088, Hungary.ORCID 0000-0003-2322-9863
Béla MerkelySemmelweis University, Budapest, H-1085, Hungary.ORCID 0000-0001-6514-0723
Péter FerdinandyDepartment of Pharmacology & Pharmacotherapy, Semmelweis University, Budapest, H-1089, Hungary.ORCID 0000-0002-6424-6806
István Vályi-NagyCentral Hospital of Southern Pest, National Institute of Haematology & Infectious Diseases, Budapest, H-1097, Hungary.
Zoltán ProhászkaDepartment of Internal Medicine & Haematology, Research Laboratory, Semmelweis University, Budapest, H-1088, Hungary.ORCID 0000-0003-1761-7982
Gábor FirneiszRamgen Plc., Budapest, H-1126, Hungary.ORCID 0000-0002-9123-8131
Semmelweis University · HUNational Center for Epidemiology · HU

Funding

Ramgen Plc.
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AdultAgedBiomarkersCOVID-19C-Reactive ProteinDipeptidyl Peptidase 4FemaleHumansInpatientsInterleukin-6Logistic ModelsMaleMiddle AgedMultivariate AnalysisPrognosisRetrospective StudiesBiomarkersC-Reactive ProteinDipeptidyl Peptidase 4DPP4 protein, humanInterleukin-6circulating DPP4 activityCOVID-19disease severityDPP4mortalityprognostic biomarkerSARS-CoV-2T2DM

Identifiers

PMID35195023
PMCPMC8961475
OpenAlexW4212875802

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.