ArticleEuropean journal of neurology2022
Short- and long-term outcome and predictors in an international cohort of patients with neuro-COVID-19.
Article in European journal of neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Neuropsychiatric Involvement in Hospitalized COVID-19 Is Embedded in Multi-Organ Disease: A Retrospective Five-Axis Record-Derived Phenotype Atlas with Renal-Urinary Prognostic Dominance.Pathogens (Basel, Switzerland) · 2026Article
- Acute brain dysfunction clusters in COVID-19: a pilot machine learning-based analysis of the COVID-D cohort.Intensive care medicine experimental · 2026Article
- Postural orthostatic tachycardia syndrome is the most frequent cardiovascular autonomic disorder following COVID-19 infection or vaccination.Journal of neurology · 2025Article
- Review
- Need for awareness and surveillance of long-term post-COVID neurodegenerative disorders. A position paper from the neuroCOVID-19 task force of the European Academy of Neurology.Journal of neurology · 2025Review
- Differences in functional outcome of COVID-19 and non-COVID-19 patients with critical illness polyneuropathy/ myopathy: a multicenter cohort study.Journal of neurology · 2025Observational
- The European Academy of Neurology NeuroCOVID-19 Task Force: A lesson for the future.European journal of neurology · 2025Article
- Overview of Long COVID: Navigating the Aftermath.Journal of Brown hospital medicine · 2025Review
- European Academy of Neurology: First 10 years.European journal of neurology · 2024Review
- Impact of Long COVID-19 on Health Outcomes Among Adults With Preexisting Cardiovascular Disease and Hypertension: A Systematic Review.CJC open · 2024Review
- Increased frequency and mortality in persons with neurological disorders during COVID-19.Brain : a journal of neurology · 2024Article
- Outcome predictors of post-COVID conditions in the European Academy of Neurology COVID-19 registry.Journal of neurology · 2024Article
- Neurological complications of SARS-CoV-2 infection among solid organ transplanted patients: does immunosuppression matter?Frontiers in neurology · 2024Article
- Elevated matrix metalloproteinase‑9 expression is associated with COVID‑19 severity: A meta‑analysis.Experimental and therapeutic medicine · 2023Article
- Neurological Manifestations of SARS-CoV2 Infection: A Narrative Review.Brain sciences · 2022Review
- Neuro-Immune Interactions in Severe COVID-19 Infection.Pathogens (Basel, Switzerland) · 2022Review
- European Psychiatric Association-European Academy of Neurology statement on post-COVID syndrome.European psychiatry : the journal of the Association of European Psychiatrists · 2022Article
- Myopathy as a cause of fatigue in long-term post-COVID-19 symptoms: Evidence of skeletal muscle histopathology.European journal of neurology · 2022Article
- Short- and long-term outcome and predictors in an international cohort of patients with neuro-COVID-19.European journal of neurology · 2022Article
- Markers of blood-brain barrier disruption increase early and persistently in COVID-19 patients with neurological manifestations.Frontiers in immunology · 2022Article
Corrections and comments
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Authors and funding
36 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeDespite the increasing number of reports on the spectrum of neurological manifestations of COVID-19 (neuro-COVID), few studies have assessed short- and long-term outcome of the disease.
methodsThis is a cohort study enrolling adult patients with neuro-COVID seen in neurological consultation. Data were collected prospectively or retrospectively in the European Academy of Neurology NEuro-covid ReGistrY ((ENERGY). The outcome at discharge was measured using the modified Rankin Scale and defined as 'stable/improved' if the modified Rankin Scale score was equal to or lower than the pre-morbid score, 'worse' if the score was higher than the pre-morbid score. Status at 6 months was also recorded. Demographic and clinical variables were assessed as predictors of outcome at discharge and 6 months.
resultsFrom July 2020 to March 2021, 971 patients from 19 countries were included. 810 (83.4%) were hospitalized. 432 (53.3%) were discharged with worse functional status. Older age, stupor/coma, stroke and intensive care unit (ICU) admission were predictors of worse outcome at discharge. 132 (16.3%) died in hospital. Older age, cancer, cardiovascular complications, refractory shock, stupor/coma and ICU admission were associated with death. 262 were followed for 6 months. Acute stroke or ataxia, ICU admission and degree of functional impairment at discharge were predictors of worse outcome. 65/221 hospitalized patients (29.4%) and 10/32 non-hospitalized patients (24.4%) experienced persisting neurological symptoms/signs. 10/262 patients (3.8%) developed new neurological complaints during the 6 months of follow-up.
conclusionsNeuro-COVID is a severe disease associated with worse functional status at discharge, particularly in older subjects and those with comorbidities and acute complications of infection.
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