ReviewNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2022
Cardiovascular autonomic nervous system responses and orthostatic intolerance in astronauts and their relevance in daily medicine.
Review in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Effects of weightlessness on the cardiovascular system: a systematic review and meta-analysis.Frontiers in physiology · 2024Pooled it
- Effects of short-term hypercaloric nutrition on orthostatic tolerance in healthy individuals: a randomized controlled crossover study.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2022Trial
- Dose-dependent effects of graded altered gravity during hypovolaemia on central haemodynamics and cardiovascular autonomic regulation.Experimental physiology · 2026Article
- Cardiovascular risks and hazards associated with deep space exploration.Communications medicine · 2026Review
- Neurological complications in microgravity and long duration spaceflight.NPJ microgravity · 2026Review
- Sex-specific cardiometabolic responses during microgravity simulation in European Space Agency VIVALDI dry immersion.Communications medicine · 2026Article
- Fluid shifts are main drivers for microgravity simulation-induced immune-physiological changes: findings from the VIVALDI studies.NPJ microgravity · 2026Article
- Microgravity- induced organ and system-level deconditioning: a network physiology perspective.Frontiers in network physiology · 2026Review
- Spaceflight human optimization and performance: positioning astronauts in an operational framework to promote health, fitness, and mission readiness.Frontiers in physiology · 2026Review
- Simulated microgravity exposure markedly attenuates the baroreflex total loop gain and induces orthostatic hypotension in male rats.Physiological reports · 2025Article
- Review of microgravity's impact on cardiovascular and nervous systems in space exploration.NPJ microgravity · 2025Review
- Impact of peripheral skin cooling on neuroendocrine leukocytic and hematological reactions during Hypergravity.NPJ microgravity · 2025Article
- Effects of repeated gravity changes during parabolic flight: Evidence of the need to assist space tourists to outer space.PloS one · 2025Article
- Impact of Daily Lower-Body Negative Pressure or Cycling Followed by Venous Constrictive Thigh Cuffs on Bedrest-Induced Orthostatic Intolerance.Journal of the American Heart Association · 2024Article
- Article
- Effects of daily artificial gravity training on orthostatic tolerance following 60-day strict head-down tilt bedrest.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2023Article
- The kidney, volume homeostasis and osmoregulation in space: current perspective and knowledge gaps.NPJ microgravity · 2023Review
- Impact of daily artificial gravity on autonomic cardiovascular control following 60-day head-down tilt bed rest.Frontiers in cardiovascular medicine · 2023Article
- A Network approach to find poor orthostatic tolerance by simple tilt maneuvers.Frontiers in network physiology · 2023Article
- Cardiac function, structural, and electrical remodeling by microgravity exposure.American journal of physiology. Heart and circulatory physiology · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundThe harsh environmental conditions during space travel, particularly weightlessness, impose a major burden on the human body including the cardiovascular system. Given its importance in adjusting the cardiovascular system to environmental challenges, the autonomic nervous system has been in the focus of scientists and clinicians involved in human space flight. This review provides an overview on human autonomic research under real and simulated space conditions with a focus on orthostatic intolerance.
methodsThe authors conducted a targeted literature search using Pubmed.
resultsOverall, 120 articles were identified and included in the review.
conclusionsPostflight orthostatic intolerance is commonly observed in astronauts and could pose major risks when landing on another celestial body. The phenomenon likely results from changes in volume status and adaptation of the autonomic nervous system to weightlessness. Over the years, various non-pharmacological and pharmacological countermeasures have been investigated. In addition to enabling safe human space flight, this research may have implications for patients with disorders affecting cardiovascular autonomic control on Earth.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.