Evidence map›Paper›PMID 35194746›Full record

ArticleJournal of general internal medicine2022

Comparative Effectiveness and Safety of Intrauterine Contraception and Tubal Ligation.

Eleanor Bimla Schwarz, Carrie A Lewis, Melanie S Dove, Eryn Murphy, Diana Zuckerman, Claudia Nunez-Eddy, Daniel J Tancredi, Raegan McDonald-Mosley, Sarita Sonalkar, Mark Hathaway and 1 more

2 registry-linked trialsOpen access · hybridAbstract readComparative Study
In one paragraph

Article in Journal of general internal medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
4.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03438682 completednot on this map

Real World Effectiveness and Safety of Hysteroscopic (Essure®) Compared to Laparoscopic Sterilization

TypeobservationalSponsorYale UniversityRan2018 to 2021Enrolled89,203ConditionsSterility, Female, Contraception, Contraceptive Device, ComplicationsArmsEssure, Laparoscopic sterilization, Intrauterine Device (IUD)
NCT06296797 narecruitingnot on this mapstarted 2024, after this paper: background citation

Disseminating PCOR Findings to Reduce Racial Disparities in Surgical Sterilization

TypeinterventionalSponsorUniversity of California, San FranciscoRan2024 to 2026Enrolled650ConditionsContraception, Reproductive Behavior, Contraception BehaviorArmsControl arm: Existing educational website, Advancing Access Website
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
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  4. Review
  5. How theJournal of women's health (2002) · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 1 country.

Eleanor Bimla SchwarzDivision of General Internal Medicine, Department of Medicine at Zuckerberg San Francisco General Hospital and Trauma Center, UCSF, San Francisco, CA, USA. Eleanor.Schwarz@ucsf.edu.ORCID 0000-0002-9912-8236
Carrie A LewisCenter for Healthcare Policy and Research, UC Davis, Sacramento, CA, USA.
Melanie S DoveCenter for Healthcare Policy and Research, UC Davis, Sacramento, CA, USA.
Eryn MurphyCenter for Healthcare Policy and Research, UC Davis, Sacramento, CA, USA.
Diana ZuckermanNational Center for Health Research, Washington, DC, USA.
Claudia Nunez-EddyNational Center for Health Research, Washington, DC, USA.
Daniel J TancrediCenter for Healthcare Policy and Research, UC Davis, Sacramento, CA, USA.
Raegan McDonald-MosleyPlanned Parenthood of Maryland, Baltimore, MD, USA.
Sarita SonalkarPerelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Mark HathawayReproductive Health and Family Planning, JHPIEGO, Washington, DC, USA.
Aileen M GariepyYale Department of Obstetrics, Gynecology and Reproductive Sciences, New Haven, CT, USA.
Center For Policy Research · USNational Center for Health Research · USPlanned Parenthood · USSan Francisco General Hospital · USUniversity of Pennsylvania · USYale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
NCATS NIH HHS UL1 TR001863Patient-Centered Outcomes Research Institute 1609-36359
6 · The paper itself

Abstract

backgroundTubal ligation remains common in the USA, especially among low-income patients.

objectiveTo compare the effectiveness and safety of intrauterine contraceptives (IUC) to laparoscopic tubal ligation for Medicaid clients.

designWe partnered with patient and clinician stakeholders to conduct a retrospective cohort study using California Medicaid claims for patients who had an IUC placed or laparoscopic tubal ligation performed in 2008-2014, excluding procedures performed within 42 days of a birth. We applied log-linear (Poisson) event-history regression models for clustered person-period data to adjust for sociodemographic variables and pre-procedure health status when examining associations between these contraceptive procedures and claims related to contraceptive failure, complications, and pain in the first year post-procedure. KEY

resultsWe identified 35,705 patients who had a levonorgestrel IUC placed, 23,628 patients who had a copper IUC placed, and 23,965 patients who underwent laparoscopic tubal ligation. In unadjusted analyses, rates of pregnancy within 1 year were similar following levonorgestrel IUC (2.40%) or copper IUC placement (2.99%) or tubal ligation (2.64%). In adjusted analyses, compared to tubal ligation, pregnancy was less common following placement of a levonorgestrel IUC (adj IRR 0.72, 95% CI 0.64-0.82) and similar with placement of a copper IUC (adj IRR 0.92, 95% CI 0.82-1.05). Procedural complications such as infection (0.35% vs. 2.91%) were significantly less common with IUC placement than tubal ligation. Claims for pelvic and abdominal pain decreased in frequency with time since all procedures; 6 to 12 months post-procedure, pelvic pain claims were less common after levonorgestrel IUC (adj IRR 0.69, 95% CI 0.65-0.73) or copper IUC placement (adj IRR 0.70, 95% CI 0.66-0.75) than tubal ligation.

conclusionsIUC appears at least as effective as laparoscopic tubal ligation at 1-year post-procedure with lower rates of infection and pelvic pain 6 to 12 months post-procedure. CLINICAL

trial registrationNCT03438682.

Indexed as

Sterilization, TubalContraceptionCopperFemaleHumansLevonorgestrelPelvic PainPregnancyRetrospective StudiesUnited StatesCopperLevonorgestrelcomparative effectivenessdisparitiesfemale sterilizationintrauterine contraceptionlow incomeMedicaidpermanent contraceptionreproductive justicetubal ligation

Identifiers

PMID35194746
PMCPMC8863411
OpenAlexW4213419365

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.