Evidence map›Paper›PMID 35194728›Full record

ArticleJournal of autism and developmental disorders2023

Childhood Academic Performance: A Potential Marker of Genetic Liability to Autism.

Janna Guilfoyle, Molly Winston, John Sideris, Gary E Martin, Kritika Nayar, Lauren Bush, Tom Wassink, Molly Losh

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of autism and developmental disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 96% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Janna GuilfoyleRoxelyn and Richard Pepper Department of Communication Sciences and Disorders, Northwestern University, 2240 N Campus Dr., Evanston, IL, 60208, USA.
Molly WinstonRoxelyn and Richard Pepper Department of Communication Sciences and Disorders, Northwestern University, 2240 N Campus Dr., Evanston, IL, 60208, USA.
John SiderisUniversity of Southern California, Los Angeles, USA.
Gary E MartinSt. John's University, New York, USA.
Kritika NayarRoxelyn and Richard Pepper Department of Communication Sciences and Disorders, Northwestern University, 2240 N Campus Dr., Evanston, IL, 60208, USA.
Lauren BushRoxelyn and Richard Pepper Department of Communication Sciences and Disorders, Northwestern University, 2240 N Campus Dr., Evanston, IL, 60208, USA.
Tom WassinkUniversity of Iowa, Iowa City, USA.
Molly LoshRoxelyn and Richard Pepper Department of Communication Sciences and Disorders, Northwestern University, 2240 N Campus Dr., Evanston, IL, 60208, USA. m-losh@northwestern.edu.ORCID http://orcid.org/0000-0002-9823-8249
Northwestern University · USSt. John's University · USUniversity of Iowa · USUniversity of Southern California · US

Funding

A Family-Genetic Study of Language in AutismR01DC010191 · NIDCD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Molly C Losh · 2010 to 2026
$7.8M
Research Management & Experimental Tools ResourcesP30DC012035 · NIDCD · NORTHWESTERN UNIVERSITY · PI LARSON, CHARLES R · 2013 to 2017
$2.3M
Perception and central coherence in autism: A family genetic eye-tracking studyR03MH107834 · NIMH · NORTHWESTERN UNIVERSITY · PI LOSH, MOLLY C · 2016 to 2017
$147k
Autism Speaks 1337NIDCD NIH HHS P30 DC012035NIDCD NIH HHS R01 DC010191NIMH NIH HHS R03 MH107834
6 · The paper itself

Abstract

Autism spectrum disorder (ASD), a heritable neurodevelopmental disorder, confers genetic liability that is often expressed among relatives through subclinical, genetically-meaningful traits, or endophenotypes. For instance, relative to controls, parents of individuals with ASD differ in language-related skills, with differences emerging in childhood. To examine ASD-related endophenotypes, this study investigated developmental academic profiles among clinically unaffected siblings of individuals with ASD (n = 29). Lower performance in language-related skills among siblings mirrored previously-reported patterns among parents, which were also associated with greater subclinical ASD-related traits in themselves and their parents, and with greater symptom severity in their sibling with ASD. Findings demonstrated specific phenotypes, derived from standardized academic testing, that may represent childhood indicators of genetic liability to ASD in first-degree relatives.

Indexed as

Autism Spectrum DisorderAutistic DisorderCognitionEndophenotypesHumansParentsSiblingsAcademicsAutism spectrum disorderBroad autism phenotypeEndophenotypeLanguage

Identifiers

PMID35194728
PMCPMC9932999
OpenAlexW4226125226

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.