SynthesisSurgical endoscopy2022
Comparison of long-term outcomes of endoscopic submucosal dissection and surgery for undifferentiated-type early gastric cancer meeting the expanded criteria: a systematic review and meta-analysis.
Synthesis in Surgical endoscopy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 19 citations in OpenAlex.
- Analysis of influencing factors of lymph node metastasis in elderly patients with early gastric cancer and establishment of a prediction model.Discover oncology · 2026Article
- A combined approach using conventional endoscopy and endoscopic ultrasonography findings yields a highly accurate diagnosis of T2-muscularis propria gastric cancer.Clinical endoscopy · 2026Article
- Non-Curative Endoscopic Submucosal Dissection: Current Concepts, Pitfalls and Future Perspectives.Journal of clinical medicine · 2025Review
- Effect of endoscopic submucosal dissection on gastrointestinal function and nutritional status in patients with early gastric cancer.World journal of gastrointestinal oncology · 2024Article
- Latest guideline of endoscopic submucosal dissection of early gastric cancer may not be suitable for Chinese patients: retrospective study findings from two centers.Surgical endoscopy · 2024Article
- Clinical Outcome of Endoscopic Submucosal Dissection for Papillary Type Early Gastric Cancer: A Multicenter Study.Gut and liver · 2024Article
- Clinical outcome of non-curative endoscopic submucosal dissection for early gastric cancer.Journal of gastrointestinal oncology · 2024Article
- Long-term Outcomes of Patients With Early Gastric Cancer Who Had Lateral Resection Margin-Positive Tumors Based on Pathology Following Endoscopic Submucosal Dissection.Journal of gastric cancer · 2024Article
- Efficacy and safety of endoscopic submucosal dissection for early gastric cancer and precancerous lesions in elderly patients.World journal of gastrointestinal surgery · 2024Article
- Early gastric cancer recurrence after endoscopic submucosal dissection: Not to be ignored!World journal of gastrointestinal oncology · 2024Article
- Performance of endoscopic submucosal dissection for undifferentiated early gastric cancer: a multicenter retrospective cohort.Endoscopy international open · 2023Article
- Review
- Development ofFrontiers in pharmacology · 2023Article
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere have been concerns over the long-term outcomes of endoscopic submucosal dissection (ESD) for undifferentiated-type early gastric cancer (UD EGC). We aimed to compare the long-term outcomes of ESD and surgery for patients with UD EGC.
methodsWe searched PubMed, Embase, and Cochrane Library databases through March 2021 to identify studies that compared the long-term outcomes of ESD and surgery for UD EGC meeting expanded criteria for curative resection. The risk of bias was assessed with the Cochrane tool for non-randomized studies. The risk ratio (RR) was estimated using a fixed-effect model.
resultsOverall, 1863 patients from five retrospective cohort studies, including 908 patients with propensity score matching (PSM), were eligible for meta-analysis. ESD was associated with inferior overall survival (OS) compared to surgery in the overall cohort (RR 2.11; 95% CI 1.26-3.55) but not in the PSM cohort (RR 1.18; 95% CI 0.60-2.32). In the PSM cohort, ESD had a lower disease-free survival (DFS) (RR 2.49; 95% CI 1.42-4.35) and higher recurrence (RR 12.61; 95% CI 3.43-46.37), gastric recurrence (RR 11.25; 95% CI 3.06-41.40), and extragastric recurrence (RR 4.23; 95% CI 0.47-37.93). Recurrence outcomes were similar between the overall and PSM cohorts. Disease-specific survival was not significantly different between the two groups in both the overall and PSM cohorts.
conclusionAlthough OS after curative ESD for UD EGC was not different from that after surgery in the PSM cohort, DFS and recurrence were inferior after ESD. Limitations included a lack of randomized trials. Further prospective studies comparing the long-term outcomes of ESD and surgery for UD EGC are needed (PROSPERO CRD 42021237097).
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