ArticleThe Journal of antimicrobial chemotherapy2022
One Health compartmental analysis of ESBL-producing Escherichia coli on Reunion Island reveals partitioning between humans and livestock.
Article in The Journal of antimicrobial chemotherapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 45 citations in OpenAlex.
- Wastewater treatment configuration shapes ESBL- and KPC-producing gram-negative bacteria in effluents from a Colombian city: a one health perspective.Journal of water and health · 2026Article
- The Wildlife-Livestock Interface as a Bidirectional Pathway for the Spread of ESBL-ProducingAnimals : an open access journal from MDPI · 2026Review
- Tracking Extended-Spectrum β-Lactamase-ProducingAntibiotics (Basel, Switzerland) · 2026Article
- From clinics to sewers: leveraging environmental surveillance and whole genome sequencing to inform transmission of ESBL-Applied and environmental microbiology · 2026Article
- NGS-Based Genomic Characterization of ESBL/AmpC-Producing Extraintestinal PathogenicAntibiotics (Basel, Switzerland) · 2026Article
- Spread of extended-spectrum β-lactamase-producing Enterobacterales (ESBL-E) in the community living spaces of patients identified as ESBL-E carriers: impact of the housing density in an African context.Tropical medicine and health · 2026Article
- Cross-sectoral sharing of CTX-M-producingMicrobiology spectrum · 2026Article
- A One Health Comparative Study of MDRAntibiotics (Basel, Switzerland) · 2025Article
- Tracking Extended-Spectrum Beta Lactamase-ProducingOpen forum infectious diseases · 2025Article
- Unexplained High Prevalence of ESBL-Antibiotics (Basel, Switzerland) · 2025Article
- Genomic epidemiology of third-generation cephalosporin-resistantOne health (Amsterdam, Netherlands) · 2025Article
- Genomic characterization of extended-spectrum β-lactamase-producingApplied and environmental microbiology · 2025Article
- Characterization of antibiotic determinants and heavy metal resistance genes inMicrobial genomics · 2025Article
- Genomic insights into extended-spectrumJournal of medical microbiology · 2025Article
- Detection of theOpen veterinary journal · 2025Article
- Integration sites ofFrontiers in microbiology · 2025Article
- Review
- Gut colonization by extended-spectrum β-lactamase-producing Escherichia coli in dairy herd in Brazil: successful dissemination of a One Health clone.Veterinary research communications · 2024Article
- Extended-Spectrum Beta-Lactamase-ProducingAntibiotics (Basel, Switzerland) · 2024Review
- Exploring Extended-Spectrum Beta-Lactamase (ESBL)-ProducingPathogens (Basel, Switzerland) · 2024Review
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Authors and funding
18 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundExtended-spectrum β-lactamase-producing Escherichia coli (ESBL-Ec) is a major cause of infections worldwide. An understanding of the reservoirs and modes of transmission of these pathogens is essential, to tackle their increasing frequency.
objectivesWe investigated the contributions of various compartments (humans, animals, environment), to human colonization or infection with ESBL-Ec over a 3 year period, on an island.
methodsThe study was performed on Reunion Island (Southwest Indian Ocean). We collected ESBL-Ec isolates prospectively from humans, wastewater and livestock between April 2015 and December 2018. Human specimens were recovered from a regional surveillance system representative of the island's health facilities. These isolates were compared with those from livestock and urban/rural wastewater, by whole-genome sequencing.
resultsWe collected 410 ESBL-Ec isolates: 161 from humans, 161 from wastewater and 88 from animals. Phylogenomic analysis demonstrated high diversity (100 STs), with different STs predominating among isolates from humans (ST131, ST38, ST10) and animals (ST57, ST156). The large majority (90%) of the STs, including ST131, were principally associated with a single compartment. The CTX-M-15, CTX-M-27 and CTX-M-14 enzymes were most common in humans/human wastewater, whereas CTX-M-1 predominated in animals. Isolates of human and animal origin had different plasmids carrying blaCTX-M genes, with the exception of a conserved IncI1-ST3 blaCTX-M-1 plasmid.
conclusionsThese molecular data suggest that, despite their high level of contamination, animals are not a major source of the ESBL-Ec found in humans living on this densely populated high-income island. Public health policies should therefore focus primarily on human-to-human transmission, to prevent human infections with ESBL-Ec.
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