Evidence map›Paper›PMID 35194565›Full record

ArticleJACC. Basic to translational science2022

Erythrocytes Induce Vascular Dysfunction in COVID-19.

Ali Mahdi, Aida Collado, John Tengbom, Tong Jiao, Tigist Wodaje, Niclas Johansson, Filip Farnebo, Anna Färnert, Jiangning Yang, Jon O Lundberg and 2 more

Open access · goldAbstract read
In one paragraph

Article in JACC. Basic to translational science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
4.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 42 citations in OpenAlex.

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  16. The ultimate tradeoff: how red cell adaptations to malaria alter the host response during critical illness.American journal of physiology. Lung cellular and molecular physiology · 2023
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Ali MahdiDivision of Cardiology, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Aida ColladoDivision of Cardiology, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
John TengbomDivision of Cardiology, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Tong JiaoDivision of Cardiology, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Tigist WodajeDivision of Cardiology, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Niclas JohanssonDivision of Infectious Diseases, Department of Medicine Solna, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.
Filip FarneboDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
Anna FärnertDivision of Infectious Diseases, Department of Medicine Solna, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.
Jiangning YangDivision of Cardiology, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Jon O LundbergDepartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Zhichao ZhouDivision of Cardiology, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
John PernowDivision of Cardiology, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Karolinska Institutet · SEKarolinska University Hospital · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Current knowledge regarding mechanisms underlying cardiovascular complications in patients with COVID-19 is limited and urgently needed. We shed light on a previously unrecognized mechanism and unravel a key role of red blood cells, driving vascular dysfunction in patients with COVID-19 infection. We establish the presence of profound and persistent endothelial dysfunction

Indexed as

ACh, acetylcholinearginaseC19-RBC, red blood cell from patients with COVID-19COVID-19EDR, endothelium-dependent relaxationEIR, endothelium-independent relaxationendothelial dysfunctionHNE, hydroxynonenalH-RBC, red blood cell from healthy subjectsIFN, interferonnitric oxideRBC, red blood cellreactive oxygen speciesred blood cellsRHI, reactive hyperemia indexROS, reactive oxygen speciesSNP, sodium nitroprussideTNF, tumor necrosis factor

Identifiers

PMID35194565
PMCPMC8849181
OpenAlexW4213300961

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.