ArticleEuropean physical journal plus2022
3D simulation of microfluidic biosensor for SARS-CoV-2 S protein binding kinetics using new reaction surface design.
Article in European physical journal plus, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Biosensor-Based Detection of Calprotectin and Lactoferrin as Neutrophil-Derived Markers of Inflammatory Bowel Diseases: From Molecular Pathophysiology to Point-of-Care Platforms.International journal of molecular sciences · 2026Review
- Optimizing microfluidic chip for rapid SARS-CoV-2 detection using Taguchi method and artificial neural network PSO.Scientific reports · 2025Article
- Optimizing PCF-SPR sensor design through Taguchi approach, machine learning, and genetic algorithms.Scientific reports · 2024Article
- Numerical optimization of microfluidic biosensor detection time for the SARS-CoV-2 using the Taguchi method.Indian journal of physics and proceedings of the Indian Association for the Cultivation of Science (2004) · 2023Article
- Taguchi method: artificial neural network approach for the optimization of high-efficiency microfluidic biosensor for COVID-19.European physical journal plus · 2023Article
- Numerical simulation and optimization of AC electrothermal microfluidic biosensor for COVID-19 detection through Taguchi method and artificial network.European physical journal plus · 2023Article
- Liquid Crystal Biosensors: Principles, Structure and Applications.Biosensors · 2022Review
- Propagation of H1N1 virus through saliva movement in oesophagus: a mathematical model.European physical journal plus · 2022Article
- Taguchi optimization of integrated flow microfluidic biosensor for COVID-19 detection.European physical journal plus · 2022Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, we performed 3D finite element simulations on the binding reaction kinetics of SARS-CoV-2 S protein (target analyte) and its corresponding immobilized antibody (ligand) in a heterogeneous microfluidic immunoassay. Two types of biosensors with two different shapes and geometries of the reaction surface and electrodes were studied. Alternating current electrothermal (ACET) force was applied to improve the binding efficiency of the biomolecular pairs by accelerating the transport of analytes to the binding surface. The ACET force stirs the flow field, thereby reducing the thickness of the diffusion boundary layer, often developed on the reaction surface due to the slow flow velocity, low analyte diffusion coefficient, and surface reaction high rate. The results showed that the detection time of one of the biosensors can be improved by 69% under an applied voltage of 10 Vrms and an operating frequency of 100 kHz. Certain control factors such as the thermal boundary conditions as well as the electrical conductivity of the buffer solution were analyzed in order to find the appropriate values to improve the efficiency of the biosensor.
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Registered trials
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