Multifarious global flora fabricated phytosynthesis of silver nanoparticles: a green nanoweapon for antiviral approach including SARS-CoV-2.

The progressive research into the nanoscale level upgrades the higher end modernized evolution with every field of science, engineering, and technology. Silver nanoparticles and their broader range of application from nanoelectronics to nano-drug delivery systems drive the futuristic direction of nanoengineering and technology in contemporary days. In this review, the green synthesis of silver nanoparticles is the cornerstone of interest over physical and chemical methods owing to its remarkable biocompatibility and idiosyncratic property engineering. The abundant primary and secondary plant metabolites collectively as multifarious phytochemicals which are more peculiar in the composition from root hair to aerial apex through various interspecies and intraspecies, capable of reduction, and capping with the synthesis of silver nanoparticles. Furthermore, the process by which intracellular, extracellular biological macromolecules of the microbiota reduce with the synthesis of silver nanoparticles from the precursor molecule is also discussed. Viruses are one of the predominant infectious agents that gets faster resistance to the antiviral therapies of traditional generations of medicine. We discuss the various stages of virus targeting of cells and viral target through drugs. Antiviral potential of silver nanoparticles against different classes and families of the past and their considerable candidate for up-to-the-minute need of complete addressing of the fulminant and opportunistic global pandemic of this millennium SARS-CoV2, illustrated through recent silver-based formulations under development and approval for countering the pandemic situation. Graphical abstract: