Evidence map›Paper›PMID 35194445›Full record

ArticleIranian journal of pharmaceutical research : IJPR2021

Preparation and Preliminary Evaluation of Dual-functional Nanoparticles for MRI and siRNA Delivery.

Jingxin Sun, Yuanfei Zhou, Guangyu Jin, Yong Jin, Jishan Quan

Abstract read
In one paragraph

Article in Iranian journal of pharmaceutical research : IJPR, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jingxin SunDepartment of Pharmaceutics, College of Pharmacy, Yanbian University, Yanji 133000, China.
Yuanfei ZhouDepartment of Pharmaceutics, College of Pharmacy, Yanbian University, Yanji 133000, China.
Guangyu JinDepartment of Radiology, Yanbian University Hospital, Yanji 133000, China.
Yong JinDepartment of Pharmaceutics, College of Pharmacy, Yanbian University, Yanji 133000, China.
Jishan QuanDepartment of Pharmaceutics, College of Pharmacy, Yanbian University, Yanji 133000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In order to improve the transfection efficiency of gene vectors and monitor the effect of gene therapy, this study prepared a drug delivery vector with dual functions. The thiourea reaction was used to synthesize polyethyleneimine (PEI, MW: 1.8 kDa) with superparamagnetic iron oxide nanoparticles (SPION) (PEI1800-SPION), and the lipid polycationic gene vector PEI1800-SPION loaded cationic liposome (LP-PEI1800-SPION) was further prepared by ethanol injection method. Agarose gel electrophoresis experiment, cytotoxicity experiment, and

Indexed as

Gene silencingLipid polycationMagnetic resonance imagingsiRNASuperparamagnetic iron oxide nanoparticles

Identifiers

PMID35194445
PMCPMC8842602

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.