Evidence map›Paper›PMID 35194263›Full record

ArticlePharmaceutical chemistry journal2022

Bioavailability and Safety of Dihydroquercetin (Review).

S V Orlova, V V Tatarinov, E A Nikitina, A V Sheremeta, V A Ivlev, V G Vasil'ev, K V Paliy, S V Goryainov

Open access · bronzeAbstract read
In one paragraph

Article in Pharmaceutical chemistry journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Bioactivity Assessment of Functionalized TiOInternational journal of molecular sciences · 2025
    Article
  12. Unraveling the Bioactive Potential ofPharmaceuticals (Basel, Switzerland) · 2024
    Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Dihydroquercetin/Taxifolin Inhibits METTL3/mKidney diseases (Basel, Switzerland)
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

S V OrlovaPeoples' Friendship University of Russia (RUDN), 6 Miklukho-Maklaya St., Moscow, 117198 Russia.
V V TatarinovA. P. Vinogradov Institute of Geochemistry, Siberian Branch, Russian Academy of Sciences, 1A Favorskogo St., P. O. Box 9, Irkutsk, 664033 Russia.
E A NikitinaPeoples' Friendship University of Russia (RUDN), 6 Miklukho-Maklaya St., Moscow, 117198 Russia.
A V SheremetaPeoples' Friendship University of Russia (RUDN), 6 Miklukho-Maklaya St., Moscow, 117198 Russia.
V A IvlevPeoples' Friendship University of Russia (RUDN), 6 Miklukho-Maklaya St., Moscow, 117198 Russia.
V G Vasil'evPeoples' Friendship University of Russia (RUDN), 6 Miklukho-Maklaya St., Moscow, 117198 Russia.
K V PaliyPeoples' Friendship University of Russia (RUDN), 6 Miklukho-Maklaya St., Moscow, 117198 Russia.
S V GoryainovPeoples' Friendship University of Russia (RUDN), 6 Miklukho-Maklaya St., Moscow, 117198 Russia.
Peoples' Friendship University of Russia · RUVinogradov Institute of Geochemistry · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dihydroquercetin (DHQ) is a bioflavonoid with high antioxidant, capillary-protective, and anti-inflammatory activity. DHQ has previously been used for treating Middle East respiratory syndrome coronavirus (MERS-CoV) infection and is currently considered a potential regulator of oxidative stress as part of COVID-19 multipurpose therapy. DHQ has a high safety profile but low bioavailability that limits its use. Innovative techniques (liposomization, crystal engineering, etc.) can be used to increase its bioavailability.

Indexed as

bioavailabilitydihydroquercetinsafetySARS-CoV-2toxicity

Identifiers

PMID35194263
PMCPMC8831168
OpenAlexW4211085165

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.