SynthesisPediatric research2024
Cerebral near-infrared spectroscopy monitoring (NIRS) in children and adults: a systematic review with meta-analysis.
Synthesis in Pediatric research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- 2024 EACTS/EACTAIC/EBCP Guidelines on cardiopulmonary bypass in adult cardiac surgery.British journal of anaesthesia · 2025Guideline
- Simultaneous bispectral index and near-infrared spectroscopy monitoring to evaluate two induction protocols in elective cardiovascular surgery.Journal of cardiothoracic surgery · 2026Trial
- Alternative consent methods used in the multinational, pragmatic, randomised clinical trial SafeBoosC-III.Trials · 2024Trial
- Trial
- Association Between Pain, Agitation, and Intracranial Pressure with Cerebral Near-Infrared Spectroscopy in Critically Ill Children: A Prospective Pilot Study.Journal of clinical medicine · 2026Article
- Article
- Cerebral protection strategies in aortic arch surgery: a review of techniques and outcomes.Annals of cardiothoracic surgery · 2026Article
- Advances in fully integrated wearable near-infrared spectroscopy: hardware innovations and biomedical applications.JPhys photonics · 2026Review
- Article
- Spinal cord vascular autoregulation: key concepts and opportunities to improve management.Spinal cord · 2026Review
- Near-infrared spectroscopy cerebral oximetry in pediatric congenital heart disease with cardiopulmonary bypass: a narrative review of current evidence and neuroprotection.Frontiers in pediatrics · 2026Review
- Association of renal regional tissue oxygen saturation and post-procedural acute kidney injury following transcatheter aortic valve implantation.Journal of clinical monitoring and computing · 2025Observational
- A Prospective Observational Study of Intraoperative Regional Cerebral Desaturation and Negative Postoperative Behavioural Changes After Non-Cardiac Paediatric Surgery.Acta anaesthesiologica Scandinavica · 2025Observational
- Macro- and microcirculation characteristics in the territory of the anterior cerebral artery in infants with congenital heart diseases.Heart and vessels · 2025Observational
- Stroke in pediatric ventricular assist device support.JHLT open · 2025Article
- Extending the Branches of Neonatal Neurocritical Care.Seminars in perinatology · 2025Review
- Classify the fNIRS signals of first-episode drug-naive MDD patients with or without suicidal ideation using machine learning.BMC psychiatry · 2025Article
- Cerebral Near-Infrared Spectroscopy and Electrical Cardiometry During Endotracheal Suction in Ventilated Infants Following Surgery: A Feasibility Study.Life (Basel, Switzerland) · 2025Article
- Reference values for cerebral and peripheral tissue oximetry in children: A clinical TD-NIRS study.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- 2024 EACTS/EACTAIC/EBCP Guidelines on cardiopulmonary bypass in adult cardiac surgery.Interdisciplinary cardiovascular and thoracic surgery · 2025Article
Corrections and comments
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Authors and funding
12 authors at 20 institutions in 13 countries.
Funding
Abstract
backgroundCerebral oxygenation monitoring utilising near-infrared spectroscopy (NIRS) is increasingly used to guide interventions in clinical care. The objective of this systematic review with meta-analysis and Trial Sequential Analysis is to evaluate the effects of clinical care with access to cerebral NIRS monitoring in children and adults versus care without.
methodsThis review conforms to PRISMA guidelines and was registered in PROSPERO (CRD42020202986). Methods are outlined in our protocol (doi: 10.1186/s13643-021-01660-2).
resultsTwenty-five randomised clinical trials were included (2606 participants). All trials were at a high risk of bias. Two trials assessed the effects of NIRS during neonatal intensive care, 13 during cardiac surgery, 9 during non-cardiac surgery and 1 during neurocritical care. Meta-analyses showed no significant difference for all-cause mortality (RR 0.75, 95% CI 0.51-1.10; 1489 participants; I
conclusionThe evidence on the effects of clinical care with access to cerebral NIRS monitoring is very uncertain. IMPACT: The evidence of the effects of cerebral NIRS versus no NIRS monitoring are very uncertain for mortality, neuroprotection, and serious adverse events. Additional trials to obtain sufficient information size, focusing on lowering bias risk, are required. The first attempt to systematically review randomised clinical trials with meta-analysis to evaluate the effects of cerebral NIRS monitoring by pooling data across various clinical settings. Despite pooling data across clinical settings, study interpretation was not substantially impacted by heterogeneity. We have insufficient evidence to support or reject the clinical use of cerebral NIRS monitoring.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.