Evidence map›Paper›PMID 35194137›Full record

ArticleCommunications biology2022

Hemojuvelin deficiency promotes liver mitochondrial dysfunction and predisposes mice to hepatocellular carcinoma.

Abdolamir Allameh, Nico Hüttmann, Edouard Charlebois, Angeliki Katsarou, Wen Gu, Konstantinos Gkouvatsos, Elisa Pasini, Mamatha Bhat, Zoran Minic, Maxim Berezovski and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Oxidative Stress in Liver Pathophysiology and Disease.Antioxidants (Basel, Switzerland) · 2023
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 4 countries.

Abdolamir Allameh *Lady Davis Institute for Medical Research and Department of Medicine, McGill University, Montreal, QC, Canada.
Nico Hüttmann *Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, ON, Canada.ORCID http://orcid.org/0000-0001-9321-2675
Edouard Charlebois *Lady Davis Institute for Medical Research and Department of Medicine, McGill University, Montreal, QC, Canada.
Angeliki KatsarouLady Davis Institute for Medical Research and Department of Medicine, McGill University, Montreal, QC, Canada.
Wen GuLady Davis Institute for Medical Research and Department of Medicine, McGill University, Montreal, QC, Canada.
Konstantinos GkouvatsosLady Davis Institute for Medical Research and Department of Medicine, McGill University, Montreal, QC, Canada.
Elisa PasiniAjmera Transplant Program, and Division of Gastroenterology and Hepatology, University Health Network, Toronto, ON, Canada.
Mamatha BhatAjmera Transplant Program, and Division of Gastroenterology and Hepatology, University Health Network, Toronto, ON, Canada.
Zoran MinicDepartment of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, ON, Canada.
Maxim BerezovskiDepartment of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, ON, Canada.ORCID http://orcid.org/0000-0003-0514-599X
Maria GuidoDepartment of Medicine, University of Padova, Padova, Italy.
Carine FillebeenLady Davis Institute for Medical Research and Department of Medicine, McGill University, Montreal, QC, Canada.
Kostas PantopoulosLady Davis Institute for Medical Research and Department of Medicine, McGill University, Montreal, QC, Canada. kostas.pantopoulos@mcgill.ca.ORCID http://orcid.org/0000-0002-2305-0057
McGill University · CAUniversity of Ottawa · CAUniversity Health Network · CAGymnase de Nyon · CHTarbiat Modares University · IRUniversity of Padua · IT

Funding

Gouvernement du Canada | Canadian Institutes of Health Research (Instituts de Recherche en Santé du Canada) PJT-159730
6 · The paper itself

Abstract

Hemojuvelin (HJV) enhances signaling to the iron hormone hepcidin and its deficiency causes iron overload, a risk factor for hepatocellular carcinoma (HCC). We utilized Hjv

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsAgedAnimalsHumansMembrane ProteinsMiceMitochondriaProteomicsMembrane Proteins

Identifiers

PMID35194137
PMCPMC8863832
OpenAlexW4213414848

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.