ArticleScientific reports2022
Motor symptom asymmetry predicts non-motor outcome and quality of life following STN DBS in Parkinson's disease.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 28 citations in OpenAlex.
- Clinical and Biological Determinants of Longitudinal Cognitive Function in Patients With GBA1 Variants and Subthalamic Deep Brain Stimulation.Annals of neurology · 2026Article
- Impact of motor symptom asymmetry on non-motor outcomes in Parkinson's disease: a systematic review.NPJ Parkinson's disease · 2025Article
- Bimanual coordination and neuromuscular synchronization in Parkinson's disease and healthy adults.Experimental brain research · 2025Article
- Unilateral and Bilateral Subthalamic Deep Brain Stimulation Differently Favour Apathy in Parkinson's Disease.The European journal of neuroscience · 2025Article
- Motor asymmetry in Parkinson's disease: Diagnostic thresholds based on clinical scores and DaTSCAN imaging.Clinical parkinsonism & related disorders · 2025Article
- Exploring the landscape of Parkinson's disease transcriptomics: a quantitative review of research progress and future directions.Frontiers in aging neuroscience · 2025Review
- Machine learning explains response variability of deep brain stimulation on Parkinson's disease quality of life.NPJ digital medicine · 2024Article
- Imbalanced motivated behaviors according to motor sign asymmetry in drug-naïve Parkinson's disease.Scientific reports · 2023Article
- Study of the relationship between onset lateralization and hemispheric white matter asymmetry in Parkinson's disease.Journal of neurology · 2023Article
- Motor Symptom Asymmetry Predicts Cognitive and Neuropsychiatric Profile Following Deep Brain Stimulation of the Subthalamic Nucleus in Parkinson's Disease: a 5-Year Longitudinal Study.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2023Article
- Moderating effects of uric acid and sex on cognition and psychiatric symptoms in asymmetric Parkinson's disease.Biology of sex differences · 2023Article
- Does Motor Symptoms Asymmetry Predict Motor Outcome of Subthalamic Deep Brain Stimulation in Parkinson's Disease Patients?Frontiers in human neuroscience · 2022Article
- Bidirectional Optogenetic Modulation of the Subthalamic Nucleus in a Rodent Model of Parkinson's Disease.Frontiers in neuroscience · 2022Article
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Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Risk factors for long-term non-motor symptoms and quality of life following subthalamic nucleus deep brain stimulation (STN DBS) have not yet been fully identified. In the present study, we investigated the impact of motor symptom asymmetry in Parkinson's disease. Data were extracted for 52 patients with Parkinson's disease (half with predominantly left-sided motor symptoms and half with predominantly right-sided ones) who underwent bilateral STN and a matched healthy control group. Performances for cognitive tests, apathy and depression symptoms, as well as quality-of-life questionnaires at 12 months post-DBS were compared with a pre-DBS baseline. Results indicated a deterioration in cognitive performance post-DBS in patients with predominantly left-sided motor symptoms. Performances of patients with predominantly right-sided motor symptoms were maintained, except for a verbal executive task. These differential effects had an impact on patients' quality of life. The results highlight the existence of two distinct cognitive profiles of Parkinson's disease, depending on motor symptom asymmetry. This asymmetry is a potential risk factor for non-motor adverse effects following STN DBS.
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