Evidence map›Paper›PMID 35194101›Full record

ArticleScientific reports2022

Screening methods for enzyme-mediated alcohol oxidation.

Martina L Contente, Irene Marzuoli, Hans Iding, Dennis Wetzl, Kurt Puentener, Steven P Hanlon, Francesca Paradisi

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 10 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Martina L ContenteDepartment of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Freistrasse 3, 3012, Bern, Switzerland.
Irene MarzuoliF. Hoffmann-La Roche Ltd, Process Chemistry and Catalysis (PCC), Grenzacherstrasse, 4070, Basel, Switzerland.
Hans IdingF. Hoffmann-La Roche Ltd, Process Chemistry and Catalysis (PCC), Grenzacherstrasse, 4070, Basel, Switzerland.
Dennis WetzlF. Hoffmann-La Roche Ltd, Process Chemistry and Catalysis (PCC), Grenzacherstrasse, 4070, Basel, Switzerland.
Kurt PuentenerF. Hoffmann-La Roche Ltd, Process Chemistry and Catalysis (PCC), Grenzacherstrasse, 4070, Basel, Switzerland.
Steven P HanlonF. Hoffmann-La Roche Ltd, Process Chemistry and Catalysis (PCC), Grenzacherstrasse, 4070, Basel, Switzerland. steven_paul.hanlon@roche.com.
Francesca ParadisiDepartment of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Freistrasse 3, 3012, Bern, Switzerland. francesca.paradisi@unibe.ch.
Roche (Switzerland) · CHUniversity of Bern · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alcohol oxidation for the generation of carbonyl groups, is an essential reaction for the preparation of fine chemicals. Although a number of chemical procedures have been reported, biocatalysis is a promising alternative for more sustainable and selective processes. To speed up the discovery of novel (bio)catalysts for industrial applications, efficient screening approaches need to be established. Here, we report on an enzyme-mediated alcohol oxidation screening platform to rapidly detect the activities and selectivities of three classes of biocatalysts; ketoreductases (KREDs), alcohol oxidases (AlcOXs) and laccase-mediator systems (LMSs) with diverse substrates.

Identifiers

PMID35194101
PMCPMC8864024
OpenAlexW4213279085

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.