ArticleTranslational psychiatry2022
Power signatures of habenular neuronal signals in patients with bipolar or unipolar depressive disorders correlate with their disease severity.
Article in Translational psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- The habenula in mood disorders: A systematic review of human studies.Molecular psychiatry · 2025Pooled it
- A Systematic Review of Aperiodic Neural Activity in Clinical Investigations.The European journal of neuroscience · 2025Pooled it
- Prefrontal-bed nucleus of the stria terminalis physiological and neuropsychological biomarkers predict therapeutic outcomes in depression.Nature communications · 2025Trial
- Behavioural and clinical biomarkers of the human bed nucleus of stria terminalis from direct neural recordings.Brain : a journal of neurology · 2026Article
- Adaptive shifts in amygdala-hippocampal theta coupling govern aversive learning and extinction.Nature communications · 2026Article
- Increased Aperiodic Exponents Track Depression Symptom Severity.bioRxiv : the preprint server for biology · 2026Article
- The Habenula's role in major depressive disorder: recent insights from preclinical and human studies.Translational psychiatry · 2026Review
- Analysis of aperiodic activity in obsessive-compulsive disorder and major depression.Scientific reports · 2025Article
- The therapeutic potential of psilocybin beyond psychedelia through shared mechanisms with ketamine.Molecular psychiatry · 2025Review
- Aperiodic (1/f) Neural Activity Robustly Tracks Symptom Severity Changes in Treatment-Resistant Depression.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- Associations Among EEG Aperiodic Slope, Infant Temperament, and Maternal Anxiety/Depression Symptoms in Infancy.Psychophysiology · 2025Article
- Subthalamic stimulation causally modulates human voluntary decision-making to stay or go.NPJ Parkinson's disease · 2024Article
- Aperiodic neural activity is a biomarker for depression severity.medRxiv : the preprint server for health sciences · 2023Article
- Risk and aversion coding in human habenula high gamma activity.Brain : a journal of neurology · 2023Article
- Structural and functional correlates of the response to deep brain stimulation at ventral capsule/ventral striatum region for treatment-resistant depression.Journal of neurology, neurosurgery, and psychiatry · 2023Article
- Frequency dependent emotion differentiation and directional coupling in amygdala, orbitofrontal and medial prefrontal cortex network with intracranial recordings.Molecular psychiatry · 2023Article
- Diencephalic organoids - A key to unraveling development, connectivity, and pathology of the human diencephalon.Frontiers in cellular neuroscience · 2023Review
- Time-locked acute alpha-frequency stimulation of subthalamic nuclei during the evaluation of emotional stimuli and its effect on power modulation.Frontiers in human neuroscience · 2023Article
- Editorial: The Habenula and Its Role in Neuropsychiatric Symptoms.Frontiers in behavioral neuroscience · 2022Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 2 countries.
Funding
Abstract
The habenula is an epithalamic structure implicated in negative reward mechanisms and plays a downstream modulatory role in regulation of dopaminergic and serotonergic functions. Human and animal studies show its hyperactivity in depression which is curtailed by the antidepressant response of ketamine. Deep brain stimulation of habenula (DBS) for major depression have also shown promising results. However, direct neuronal activity of habenula in human studies have rarely been reported. Here, in a cross-sectional design, we acquired both spontaneous resting state and emotional task-induced neuronal recordings from habenula from treatment resistant depressed patients undergoing DBS surgery. We first characterise the aperiodic component (1/f slope) of the power spectrum, interpreted to signify excitation-inhibition balance, in resting and task state. This aperiodicity for left habenula correlated between rest and task and which was significantly positively correlated with depression severity. Time-frequency responses to the emotional picture viewing task show condition differences in beta and gamma frequencies for left habenula and alpha for right habenula. Notably, alpha activity for right habenula was negatively correlated with depression severity. Overall, from direct habenular recordings, we thus show findings convergent with depression models of aberrant excitatory glutamatergic output of the habenula driving inhibition of monoaminergic systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.